赶黄草总黄酮对肾病综合征大鼠的保护作用

Protective Effect of Nephrotic Syndrome Rats with Total Flavonoids of Penthorum chinense Pursh

为研究赶黄草总黄酮对阿霉素肾病综合征模型大鼠的保护作用。本文以赶黄草总黄酮为原料,通过阿霉素诱导大鼠建立肾病综合征模型。以24 h尿蛋白定量、体质量、各脏器指数、甘油三酯(TG)、总胆固醇(TC)、总蛋白(TP)、肌酐(Scr)、尿素氮(BUN)、白蛋白(ALB)含量以及肾组织病理变化等为检测指标,探索赶黄草总黄酮对肾病综合征大鼠的影响。试验结果表明,阿霉素造模总剂量为5 mg/kg,分别于第1 d和第8 d给药,21 d即造模成功。药物干预4 w后,同模型组相比,赶黄草总黄酮高剂量组大鼠TP增加了9.86%,TC降低了36.98%,TG降低了30.77%,大鼠24 h尿蛋白量水平降低了70.84%。总黄酮低剂量组TP增加了11.86%,TG降低了19.79%,大鼠24 h尿蛋白量水平降低了57.98%,肾脏纤维化和损伤均有明显改善。赶黄草总黄酮能够调节肾病综合征模型大鼠体内脂质代谢,改善肾脏对蛋白的滤过,对肾病综合征大鼠肾损伤具有一定的保护作用。

To study the protective effect of total flavonoids from Penthorum chinense pursh on adriamycin-induced nephrotic syndrome model rats,in this article,the total flavonoids of Penthorum chinense pursh were used as materials,the rat model of nephrotic syndrome was induced by adriamycin.The amount of 24 h urine protein,body weight,organ index,triglyceride(TG),total cholesterol(TC),the total protein(TP),creatinine(Scr),urea nitrogen(BUN),albumin(ALB)content and renal tissue pathological changes were used as indicators to explore the effects of total flavonoids on nephrotic syndrome model rats.The results showed that the total dose of adriamycin was 5mg/kg,which was administered on the 1th d and 8th d respectively.The model was successfully established in 21 days.After 4 weeks of drugs intervention,compared with the model group,the TP in the high-dose group of total flavonoids increased by 9.86%,the TC decreased by 36.98%,the TG decreased by 30.77%,and the level of 24 h urine protein decreased by 70.84%.In the low-dose group of total flavonoids,the TP increased by 11.86%,the TG decreased by 19.79%,the 24 h urine protein level decreased by 57.98%,and the renal fibrosis and injury were significantly improved.The lipid metabolism in the rats model of nephrotic syndrome was regulated,the protein filtration of the kidney was improved,and the total flavonoids of Penthorum chinense pursh had a certain therapeutic effect on nephrotic syndrome.