基于关联规则和系统聚类分析的菟丝子用药规律分析

Analysis of Compatibility Rule of Dodder Weed Based on Association Rule and Systematic Cluster Analysis

目的基于关联规则和聚类分析挖掘菟丝子用药配伍规律,为临床用药及潜在新处方的研发提供参考。方法以2015年版中国药典记载的含菟丝子中成药为来源,以Excel 2013、SPSS Modeler 14.1和SPSS Statistics 19.0为统计工具对纳入中药进行关联规则和系统聚类分析。结果共搜索含菟丝子中成药46种。46种中成药包含168味中药,性味归经和功效以甘(431,51.93%)、苦(153,18.43%)、温(222,46.06%)、平(162,33.61%)、肾经(330,27.30%)、肝经(292,24.15%)和补虚药(316,65.56%)、利水渗湿药(35,7.26%)居多;剂型以丸剂(15,32.16%)、片剂(14,30.43%)居多;对组成含菟丝子中成药的高频中药进行关联规则分析,得到常用药对11种;对含菟丝子中成药的主治疾病进行统计,得到11类中医常见临床疾病。高频药物关联规则分析中发现治疗男性前阴病类和肾系病类关联强度最高的药对分别为5种和6种,高频药物聚类分析中得到治疗男性前阴病类和肾系病类的中药分别为8类和7类。结论基于关联规则和系统聚类分析挖掘得到菟丝子潜在药对组合以补虚药为主,未来可着重进行其与枸杞子、黄芪配伍在男性前阴病类,以及与枸杞子、白术、熟地黄、川芎配伍在肾系病中应用的研究,并可进行其外治疾病中成药和剂型的研究,以扩大主治病症。

OBJECTIVE To provide reference for clinical medicine the development of potential new prescriptions,based on association rules and cluster analysis discusses the rule of Chinese patent medicine contain dodder weed.METHODS Making Chinese patent medicine contain dodder weed recorded in Chinese Pharmacopoeia 2015 as the source,used Excel 2013,SPSS Modeler 14.1 and SPSS Statistics 19.0 as statistical tools to conduct association rule and cluster analysis for included medicines.RESULTS A total of 46 kinds of Chinese patent medicine contain dodder weed were searched,containing 168 kinds of Chinese medicines.Most of the medicine tastes were sweet(431,51.93%),bitter(153,18.43%),warm(222,46.06%)and neutral(162,33.61%)in property.In the channel tropism,kidney(330,27.30%)and liver(292,24.15%)were the most common.In the efficiency category,deficiency-nourishing drugs(316,65.56%)and damp-clearing drugs(35,7.26%)were the most common.The dosage forms were mainly pill(15,32.16%)and tablet(14,30.43%).The association rule analysis of the high frequency medicines among 168 kinds of medicines were carried out,and 11 kinds of common drugs were obtained.Eleven kinds of common clinical diseases in traditional Chinese medicine were obtained by statistics of the main diseases treated with Chinese patent medicine contain dodder weed.In the analysis of high-frequency drug association rules,it was found that there were 5 kinds of drug pairs with the highest correlation intensity for the treatment of male anterior Yin diseases and 6 kinds of drug pairs for the treatment of nephropathy,respectively.In the cluster analysis of high-frequency drug,eight and seven categories of traditional Chinese medicines were obtained for the treatment of male anterior Yin diseases and nephropathy,respectively.CONCLUSION Based on association rules and systematic clustering analysis,dodder potential drug combinations are found to be mainly deficiency-nourishing drugs.The future can focus on the study of its compatibility with lycium barbarum and astragalus in male anterior Yin diseases and the application of its compatibility with lycium barbarum,atractylodes alba,rehmannia rehmannii and chuanxiong in nephropathy.And can study its topical use of Chinese patent medicine and dosage forms for the treatment of diseases,in order to expand the main treatment of Chinese medicine symptoms.