TNIP1/ANXA6基因多态性与中国维吾尔族寻常型银屑病临床表型及病情相关性研究

Association between TNIP1/ANXA6 Gene Polymorphisms and Clinical Features of Psoriasis Vulgaris in a Uyghur Population from China

目的探讨人肿瘤坏死因子α诱导蛋白3 TNFAIP3相互作用蛋白1(TNIP1)/膜联蛋白A6(ANXA6)基因多态性与中国维吾尔族人群寻常型银屑病临床表型的相关性。方法收集332例维吾尔族寻常型银屑病患者和330例维吾尔族健康人群外周血目的片段DNA,选择位于TNIP1/ANXA6基因区域的2个单核苷酸多态性(SNP)rs17728338、rs999556,利用连接酶检测反应基因分型。结果维吾尔族寻常型银屑病组与对照组间TNIP1/ANXA6基因多态性rs17728338位点的基因型和等位基因分布频率比较,差异均有统计学意义(P<0.05),rs999556位点在银屑病组和对照组间基因型和等位基因分布频率比较,差异无统计学意义(P>0.05)。TNIP1/ANXA6 rs17728338分层分析中的基因型、等位基因在有家族史组与无家族史组之间、PASI评分≥10分和PASI评分<10分之间rs17728338位点基因型频率比较,差异有统计学意义(P<0.05)。结论TNIP1/ANXA6 rsl7728338位点单核苷酸多态性可能参与中国维吾尔族人群寻常型银屑病的发生和发展。

Objective To investigate the relationship between polymorphism in the human tumor necrosis factor a-induced protein 3(TNFAIP3)interacting protein 1/Annexin A6 gene(TNIP1/ANXA6)and psoriasis vulgaris in a Uyghur population from China.Methods The DNA of 332 cases of Uyghur psoriasis vulgaris and 330 healthy controls were collected.Two single nueleotide polymorphisms(SNPs)in the TNIP1/ANXA6 gene,including rs17728338 and rs999556 were selected for genotyping with ligase detection reaction(LDR).Results The genotype distributions and allele frequencies of rs17728338 were different between the Uyghur psoriasis vulgaris group and the healthy control group(P<0.05).There was no significant difference in the frequencies of genotype and allele of rs999556 between patients and controls(P>0.05).There were statistical differences in genotype distributions and alleles frequencies of rs17728338 between patients with a family history and healthy controls(P<0.05);There were statistical differences in genotype distributions and alleles frequenciesof rs17728338 between patients with the PASI score≥10 and the PASI score<10(P<0.05).Conclusion The SNP rs17728338 of TNIP1/ANXA6 gene may be involved in the occurrence and development of Chinese Uygur psoriasis vulgaris.