阿托伐他汀钙联合氢氯吡格雷治疗急性脑梗死患者颈动脉粥样硬化斑块的效果观察

Observation on Effect of Atorvastatin Calcium Combined with Hydroclopidogrel in the Treatment of Carotid Atherosclerotic Plaque in Patients with Acute Cerebral Infarction

目的探讨阿托伐他汀钙联合氢氯吡格雷治疗急性脑梗死颈动脉粥样硬化斑块的效果。方法选取我院2016年10月至2017年8月收治的86例急性脑梗死患者,根据治疗方法分为两组各43例。对照组采用氢氯吡格雷单药治疗,研究组在此基础上采用阿托伐他汀钙治疗。对比两组患者治疗前后的生化指标与颈动脉粥样硬化斑块相关指标。结果治疗前,两组患者的生化指标与颈动脉粥样硬化斑块相关指标比较均无统计学差异(P>0.05);治疗后,研究组的生化指标、颈动脉粥样硬化斑块相关指标均优于对照组(P<0.05)。结论对急性脑梗死患者采用阿托伐他汀钙联合氢氯吡格雷治疗,可有效改善患者的血脂情况,减少斑块的面积和厚度,临床疗效显著,值得应用。

Objective To explore the effect of atorvastatin calcium combined with hydroclopidogrel in the treatment of carotid atherosclerotic plaque of acute cerebral infarction.Methods 86 cases of patients with acute cerebral infarction admitted to our hospital from October 2016 to August 2017 were selected and divided into two groups according to the treatment methods,with 43 cases in each group.The control group was only treated with hydroclopidogrel,and the study group was treated with atorvastatin calcium on this basis.The biochemical indicators and carotid atherosclerotic plaque related indicators before and after treatment were compared between the two groups.Results Before treatment,no statistical difference was found in the biochemical indicators and carotid atherosclerotic plaque related indicators between the two groups(P>0.05).After treatment,the biochemical indicators and carotid atherosclerotic plaque related indicators of the study group were better than those of the control group(P<0.05).Conclusions Atorvastatin calcium combined with hydroclopidogrel in the treatment of carotid atherosclerotic plaque in patients with acute cerebral infarction can effectively improve the blood lipid,and reduce the area and thickness of plaque,with significant clinical effect,which is worthy of application.