硝普钠与酚妥拉明急诊治疗冠心病合并心力衰竭的临床疗效观察

Observation on the Clinical Effect of Sodium Nitroprusside and Phentolamine in the Emergency Treatment of Coronary Heart Disease Complicated with Heart Failure

目的观察硝普钠与酚妥拉明急诊治疗冠心病合并心力衰竭的临床疗效。方法选取我院2018年7月至2018年12月期间收治的50例冠心病合并心力衰竭患者,随机分为观察组和对照组,各25例。对照组给予甲磺酸酚妥拉明治疗,观察组给予硝普钠治疗,观察比较两组患者的临床疗效及治疗前后的心功能指标。结果观察组的治疗总有效率为96.00%,明显高于对照组的72.00%,差异有统计学意义(P<0.05)。与对照组比较,观察组治疗后的LVEF明显升高,LVESD和LVEDD明显降低,差异均有统计学意义(P<0.01)。结论在冠心病合并心力衰竭患者的急诊治疗中,硝普钠的临床疗效明显优于酚妥拉明,可有效改善患者的心功能,值得临床推广应用。

Objective To observe the clinical efficacy of sodium nitroprusside and phentolamine in the emergency treatment of coronary heart disease complicated with heart failure.Methods 50 cases of patients with coronary heart disease complicated with heart failure admitted to our hospital from July 2018 to December 2018 were selected and randomly divided into observation group and control group,with 25 cases in each group.The patients in the control group were treated with phentolamine mesylate,and the patients in the observation group were treated with sodium nitroprusside.The clinical efficacy and the cardiac function indicators before and after treatment were observed and compared between the two groups.Results The total effective rate of treatment in the observation group was 96.00%,significantly higher than 72.00%in the control group,with statistical difference(P<0.05).Compared with the control group,the LVEF of the observation group after treatment significantly increased,and the LVESD and LVEDD significantly decreased,with statistical differences(P<0.01).Conclusions In the emergency treatment of patients with coronary heart disease complicated with heart failure,sodium nitroprusside has significantly better clinical efficacy than phentolamine,and can effectively improve the heart function of patients,which is worthy of clinical promotion and application.