阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能及炎性因子的影响

Influence of Intravenous Thrombolytic Therapy with Alteplase on Neurologic Function and Inflammatory Factors of Patients with Acute Cerebral Infarction

目的探讨阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能及炎性因子的影响。方法将96例急性脑梗死患者随机分为对照组和观察组,各48例。对照组采用基础药物治疗,观察组在对照组基础上采用阿替普酶静脉溶栓治疗,比较两组患者的神经功能、炎性因子水平及不良反应发生情况。结果治疗后,观察组的NIHSS评分及TNF-α、IL-1β、hs-CRP水平均低于对照组(P<0.05)。两组的不良反应发生率比较差异无统计学意义(P>0.05)。结论采用阿替普酶静脉溶栓治疗急性脑梗死患者,可有效缓解其神经功能损伤,改善其炎症状态,且安全性较高,值得临床推广。

Objective To explore the influence of intravenous thrombolytic therapy with alteplase on neurologic function and inflammatory factors of patients with acute cerebral infarction.Methods 96 cases of patients with acute cerebral infarction were randomly divided into control group(n=48)and observation group(n=48).The control group was treated with basic drugs,and the observation group was given intravenous thrombolytic therapy with alteplase on the basis of the control group.The neurologic function,levels of inflammatory factors and adverse reactions were compared between the two groups.Results After treatment,the NIHSS score,and TNF-α,IL-1βand hs-CRP levels of the observation group were significantly lower than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Intravenous thrombolysis with alteplase in the treatment of patients with acute cerebral infarction can effectively relieve the neurologic damage and improve the inflammatory state,with higher safety,which is worthy of clinical promotion.