自噬对慢性肾脏病足细胞损伤的影响

Influence of Autophagy on Podocyte Injury in Chronic Kidney Disease

足细胞是高度分化的终末细胞,参与维持肾脏正常的滤过功能。足细胞一旦损伤,必然会加快慢性肾脏病进展,其损伤在慢性肾脏病病理过程中占据着一大地位。近年来,自噬在慢性肾脏病足细胞损伤中的研究越来越多,本文旨在对自噬在慢性肾脏病足细胞损伤中的影响进行综述。

Podocytes are highly differentiated terminal cells that are involved in maintaining normal renal filtration.Once the podocytes are damaged,it will accelerate the progression of chronic kidney disease,and its damage plays a major role in the pathological process of chronic kidney disease.In recent years,autophagy has been studied more and more in podocyte injury of chronic kidney disease.This article reviewed the role of autophagy in podocyte injury of chronic kidney disease.