诱骗受体3γ-干扰素和抗环瓜氨酸肽抗体在风湿性关节炎患者血清中的表达

Expression of Decoy Receptor 3γ-Interferon and Anti-Cyclic Citrullinated Peptide Antibody in Serum of Patients with Rheumatoid Arthritis

目的分析在风湿性关节炎患者中抗环瓜氨酸肽抗体、血清诱骗受体3γ-干扰素检验有效性。方法选择2018年1月~12月我院收治的风湿性关节炎患者50例作为观察组,另选同期体检健康人群40例作为对照组,检测并比较两组血清抗环瓜氨酸肽抗体、血清诱骗受体3γ-干扰素水平。结果观察组抗环瓜氨酸肽抗体、风湿因子检测结果高于对照组,差异有统计学意义(P<0.05);观察组单一抗环瓜氨酸肽抗体检测阳性率、单一风湿因子检测阳性率均高于对照组,观察组抗环瓜氨酸肽抗体联合风湿因子检测阳性率高于对照组,差异均有统计学意义(P<0.05);观察组抗环瓜氨酸肽抗体、血清诱骗受体3γ-干扰素含量比对照组高,差异有统计学意义(P<0.05)。结论在风湿性关节炎患者中抗环瓜氨酸肽抗体、血清诱骗受体3γ-干扰素检验,能够明确患者临床指标情况,对于临床治疗有参考价值,值得应用。

Objective To analyze the effectiveness of anti-cyclic citrullinated peptide antibody and serum decoy receptor 3γ-interferon in patients with rheumatoid arthritis.Methods 50 patients with rheumatoid arthritis admitted to our hospital from January to December 2018 were selected as observation group,and 40 healthy subjects in the same period were selected as the control group.The serum anti-cyclic citrullinated peptide antibodies were detected and compared.Serum decoy receptor 3γ-interferon levels.Results The anti-cyclic citrullinated peptide antibody and rheumatoid factor in the observation group were higher than the control group,the difference was statistically significant(P<0.05).The positive rate of single anti-cyclic citrullinated peptide antibody and the positive rate of single rheumatoid factor in the observation group.The positive rate of anti-cyclic citrullinated peptide antibody combined with rheumatoid factor was higher in the observation group than in the control group,the difference was statistically significant(P<0.05);the anti-cyclic citrullinated peptide antibody and serum decoy in the observation group The content of receptor 3γ-interferon was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion In the patients with rheumatoid arthritis,anti-cyclic citrullinated peptide antibody and serum decoy receptor 3γ-interferon test can confirm the clinical indicators of patients,which has reference value for clinical treatment and is worthy of application.