强化药学干预对喹诺酮类药物临床应用合理性的影响

Effect of Intensive Pharmaceutical Intervention on the Rationality of Clinical Application of Quinolones

目的分析喹诺酮类药物临床应用中强化药学干预对其应用合理性的影响。方法选取2017年1月~2019年1月天津市红桥医院含喹诺酮类药物处方1180张作为研究对象,其中2018年1月~2019年1月实行强化药学干预的600张处方作为观察组,将2017年1月~12月未实行强化药学干预的580张处方作为对照组,比较两组喹诺酮类药物使用频度、不合理事件发生率及耐药率。结果观察组药物使用频度为(9672.37±276.54)次,低于对照组的(12540.65±358.20)次,差异有统计学意义(P<0.05);观察组药物使用不合理事件发生率为5.33%,低于对照组的9.66%,差异有统计学意义(P<0.05);观察组铜绿假单胞菌、肺炎雷克伯菌、大肠杆菌耐药率分别为9.00%、11.33%、17.33%,低于对照组的16.90%、16.50%、26.38%,差异有统计学意义(P<0.05)。结论喹诺酮类药物临床应用中强化药学干预可降低其使用频度与耐药率,提升应用合理性。

Objective To analyze the effect of intensive pharmaceutical intervention on the rationality of its application in the clinical application of quinolones.Methods From January 2017 to January 2019,1180 prescriptions of quinolones in Tianjin Hongqiao Hospital were selected as subjects.From January 2018 to January 2019,600 prescriptions for intensive pharmaceutical intervention were used as observation groups.From January to December 2017,580 prescriptions for intensive pharmaceutical intervention were not used as the control group.The frequency of quinolones used,the incidence of irrational events and the drug resistance rate were compared.Results The frequency of drug use in the observation group was(9672.37±276.54)times,which was lower than that in the control group(12540.65±358.20),the difference was statistically significant(P<0.05).The incidence of unreasonable drug use in the observation group was 5.33%,it was lower than that of the control group 9.66%,the difference was statistically significant(P<0.05).The drug resistance rates of Pseudomonas aeruginosa,Rekburn pneumoniae and Escherichia coli in the observation group were 9.00%,11.33%and 17.33%,respectively,which were significantly lower than those in the control group 16.90%,16.50%and 26.38%,the difference was statistically significant(P<0.05).Conclusion Intensive pharmaceutical intervention in the clinical application of quinolones can reduce the frequency of use and drug resistance,and improve the rationality of application.