血清MCP-1蛋白水平对肺癌及肺结核患者诊断的临床意义

Clinical Significance of Serum MCP-1 Protein Level in the Diagnosis of Lung Cancer and Pulmonary Tuberculosis

目的探讨MCP-1蛋白表达在肺癌及肺结核患者中的临床意义。方法选取2017年1月~2018年12月我院呼吸科收治的40例肺癌及40例肺结核患者为研究对象,同时选取同期在我院体检健康人群40例为对照组,对比三组血清及PBMC上清液中MCP-1浓度及不同期、不同病理类型肺癌患者血清及PBMC上清液中MCP-1浓度和初治和复治肺结核血清及PBMC上清液中MCP-1浓度。结果肺结核组及肺癌组血清及PBMC上清液中MCP-1浓度高于对照组,且肺结核组高于肺癌组,差异有统计学意义(P<0.05);晚期肺癌患者血清及PBMC上清液中MCP-1浓度分别为(152.71±12.56)pg/ml、(419.52±33.93)pg/ml,均高于早期肺癌患者的(73.21±7.90)pg/ml、(312.60±28.62)pg/ml,差异均有统计学意义(P<0.05);三种不同病理类型肺癌患者血清及PBMC上清液中MCP-1浓度比较,差异无统计学意义(P>0.05);肺结核复治患者血清及PBMC上清液中MCP-1浓度分别为(173.65±13.22)pg/ml、(520.11±67.28)pg/ml,高于肺结核初治患者的(156.21±9.13)pg/ml、(498.34±50.03)pg/ml,差异有统计学意义(P<0.05)。结论血清MCP-1蛋白水平于肺癌及肺结核的发生、病情发展有密切的关系,且随病情的进展会升高,临床可将其作为诊治的重要指标。

Objective To investigate the clinical significance of MCP-1 protein expression in patients with lung cancer and pulmonary tuberculosis.Methods 40 patients with lung cancer and 40 patients with pulmonary tuberculosis admitted to our hospital from January 2017 to December 2018 were enrolled in the study.At the same time,40 healthy subjects in our hospital were selected as the control group,and the concentration of MCP-1 in serum and PBMC supernatant in the three groups were compared.The concentration of MCP-1 in serum and PBMC supernatant of lung cancer patients with different pathological types and the concentration of MCP-1 in serum and PBMC supernatant of newly diagnosed and retreated pulmonary tuberculosis.Results The concentration of MCP-1 in serum and PBMC supernatant of pulmonary tuberculosis group and lung cancer group was higher than that of control group,and the tuberculosis group was higher than that in lung cancer group,the difference was statistically significant(P<0.05);the concentration of MCP-1 in serum and PBMC supernatant of late stage lung cancer patients was(152.71±12.56)pg/ml、(419.52±33.93)pg/ml,which was higher than that in early stage lung cancer patients(73.21±7.90)pg/ml、(312.60±28.62)pg/ml,the difference was statistically significant(P<0.05);there was no significant difference in the concentration of MCP-1 in serum and PBMC supernatant of three different pathological types(P>0.05);the concentration of MCP-1 in serum and PBMC supernatant of retreated pulmonary tuberculosis patients was(173.65±13.22)pg/ml、(520.11±67.28)pg/ml,which was higher than that in untreated pulmonary tuberculosis patients(156.21±9.13)pg/ml、(498.34±50.03)pg/ml,the difference was statistically significant(P<0.05).Conclusion Serum MCP-1 protein level is closely related to the occurrence and development of lung cancer and tuberculosis,and it will increase with the progress of the disease.It can be used as an important indicator for diagnosis and treatment.