法尼酯衍生物X受体在胃癌中的研究进展
摘要
胆汁反流引起胃黏膜慢性炎症、化生是胃癌发生的重要始动因素。法尼酯衍生物X受体(FXR,又名NR1H4)是可被胆汁酸激活的转录因子。近年来研究发现,FXR不仅参与胆汁酸、脂质、糖类和氨基酸代谢,还与消化道恶性肿瘤的发生、发展密切相关。激活FXR对胃黏膜的慢性刺激和炎症具有防御性保护作用,而FXR缺陷则会加剧胃的炎症并促进肿瘤的发生、发展。FXR在抑制胃癌发生、发展中的作用是肯定的。
出处
《中华普通外科杂志》
CSCD
北大核心
2019年第9期822-824,共3页
Chinese Journal of General Surgery
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