中医药通过PTEN/PI3K/Akt信号通路防治糖尿病肾病的研究进展

Review on effects of traditional Chinese medicine on preventing diabetic nephropathy via PTEN/PI3K/Akt signaling pathway

糖尿病肾病(DN)是糖尿病主要的微血管并发症之一,是一种进行性、难以逆转性的肾脏损害,已成为引起终末期肾病的首要原因。蛋白尿是DN的主要临床表现,但目前其机制尚不完全明确,现代医学对此尚缺乏特效药,因此关于DN深入的分子机制仍然是研究热点。最新研究表明,PTEN/PI3K/Akt信号通路与DN的发病密切相关,同时亦是众多中药复方、中药单体常见的作用机制。因此,文章将基于PTEN/PI3K/Akt信号通路,综述中医药对该通路已有的研究成果,以期为中医药防治DN提供一定的理论基础。

Diabetic nephropathy(DN), one of the major microvascular complications of diabetes, is a progressive and irreversible renal damage, which has become the primary cause of end-stage renal disease. Proteinuria is the main clinical manifestation of DN, but its mechanism is not completely clear at present. Modern medicine still lacks specific drugs for it. Therefore, the in-depth molecular mechanism of DN is still a research hotspot. Recent studies have shown that PTEN/PI3 K/Akt signaling pathway is closely related to the pathogenesis of DN, and is also a common mechanism of action of many traditional Chinese medicine prescriptions and monomers. Therefore, based on PTEN/PI3 K/Akt signaling pathway, this paper reviews the existing research results of TCM on this pathway, with a view to providing a theoretical basis for the prevention and treatment of DN in TCM.