七味三芎汤治疗颈动脉粥样硬化斑块

Qiwei Sanxiong Decoction in the Treatment of Carotid Atherosclerotic Plaque

目的研究七味三芎汤治疗颈动脉粥样硬化斑块的影响。方法选取本院颈粥样硬化斑块89例,采用随机数字表法分为对照组44例和研究组45例。对照组给予常规西药治疗,研究组在上述基础上加服七味三芎汤,2组均以12个月为1疗程。观察2组TC、TG、HDL-C、LDL-C、IMT、Crouse、中医症候积分、支架内再狭窄发生率的变化。结果治疗后,研究组有效率为88.9%,优于对照组的70.4%,差异具有统计学意义(P <0.05)。与治疗前比较,2组治疗后的TG、TC、LDL-C降低,HDL-C增高,差异具有统计学意义(P <0.05)。研究组治疗后TG、 TC、LDL-C低于对照组,HDL-C高于对照组,差异具有统计学意义(P <0.05)。研究组治疗后IMT、Crouse积分低于对照组,差异具有统计学意义(P <0.05)。治疗12个月后,研究组支架内再狭窄率11.1%,优于对照组的29.5%,差异具有统计学意义(P <0.05)。结论七味三芎汤联合常规西药能提颈动脉粥样硬化斑块患者的临床疗效,无明显不良反应。

Objective Study on the effect of Qiwei Sanxiong decoction on carotid atherosclerotic plaque. Methods Eighty-nine patients with cervical atherosclerotic plaque were randomly divided into the control group(44 cases) and the study group(45 cases). The control group received conventional western medicine treatment. The research group added Qiwei Sanxiong decoction on the above basis. Both groups took 12 months as a course of treatment. The changes of TC, TG, HDL-C, LDL-C, IMT, Crouse, TCM symptom scores and in-stent restenosis were observed. Results After treatment, the effective rate of the study group was 70.4% to 88.9%, and the difference was statistically significant(P < 0.05). Compared with before treatment, TG, TC, LDL-C decreased and HDL-C increased after treatment, and the difference was statistically significant(P < 0.05). Compared with the control group, TG, TC and LDL-C were lower in the study group than in the control group, and HDL-C was higher than the control group(P < 0.05). Compared with the control group, the IMT and Crouse scores in the study group were lower than those in the control group, and the difference was statistically significant(P < 0.05). Compared with the control group, the in-stent restenosis rate of the study group was 11.1% vs 29.5 after 12 months of treatment, and the difference was statistically significant(P < 0.05). Conclusion Qiwei Sanxiong tang combined with conventional western medicine can improve the clinical efficacy of patients with carotid atherosclerotic plaque, no obvious adverse reactions, it is worthy of popularization and application.