外用抗真菌中草药的研究进展

Advance on Traditional Chinese Herb in the topical antifungal therapy

目前,抗真菌中草药的研究主要集中在:一、中药经验方剂的临床应用;二、中草药有效单体成分的分离纯化及其方法的改进;三、中草药有效抗真菌单体的体外药敏研究;四、中药组方在感染动物模型上的应用。药物作用于病灶,除了直接或协同抗真菌作用,也通过清热祛湿止痒的功效,减轻炎症和缓解症状;清除真菌的同时改变局部小环境,使之不利于真菌的生长。

Advance on topical antifungal traditional Chinese herb mainly focused on the following aspects:clinical application of empirical traditional Chinese medicinal formulae,identification and purification of monomers with antifungal function,in vitro antifungal sensitivity assay of monomers,in vivo application of new Chinese herb formulae or compound monomers products on the animal models of superficial mycosis,etc.The herbs themselves and their active ingredients might show direct or synergistic antifungal effects.Furthermore,they might reduce inflammation and relieve itching symptom through their traditional“Heat-Clearing and Dampness-Removing and Itching-Relieving”mechanisms.While eliminating some pathogenic fungi,they also made the local body microenvironment not beneficial for fungal growth.