补肾通络法和中药熏蒸内外合治膝骨性关节炎的临床疗效研究

Clinical effect on knee osteoarthritis treated with bushen tongluo method and Chinese herbal fumigation

目的探究补肾通络法和中药熏蒸内外合治治疗膝骨性关节炎(KOA)的临床疗效。方法将2017年1月至2017年12月期间收治的126例KOA患者采用随机数字表的方式随机分为对照组63例及治疗组63例。对照组给予KOA的常规治疗,治疗组予补肾通络法和中药熏蒸内外合治,两组均治疗4周。治疗后观察两组临床疗效、膝关节功能(WOMAC评分)、疼痛程度(VAS评分)、血清中相关炎症因子[白细胞介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)]水平变化。结果治疗过程中,共有6例患者脱落,其中对照组4例,治疗组2例,实际共有120例患者。治疗后,对照组的有效率为76.27%,治疗组为88.52%,两组比较差异有统计学意义(P<0.05)。两组患者治疗后WOMAC、VAS评分均显著下降,与治疗前比较差异有统计学意义(P<0.01),且治疗组优于对照组(P<0.01)。两组血清炎症因子治疗后改善程度与治疗前比较,差异有统计学意义(P<0.05),且治疗组优于对照组(P<0.05)。结论补肾通络法和中药熏蒸内外合治KOA可改善临床症状、膝关节功能、改善炎症因子水平,安全性好,值得临床推广。

Objective To explore the clinical effect on knee osteoarthritis(KOA)treated with bushen tongluo method and Chinese herbal fumigation.Methods From January 2017 through to December 2017,126 KOA patients were randomized into a control group(63 cases)and a treatment group(63 cases).In the control group,the routine treatment was used.In the treatment group,the combined treatment with bushen tongluo method and Chinese herbal fumigation was used.The duration of treatment was 4 weeks.The clinical effect,WOMAC score,VAS score and serum inflammatory factors(IL-1β,TNF-αand TGF-β)were observed after treatment in the two groups.Results During treatment,6 cases were dropped,4 cases in the control group and 2 cases in the treatment group.Actually,120 cases accomplished the trial.After treatment,the effective rate was 76.27%in the control group and was 88.52%in the treatment group,indicating the statistical significance(P<0.05).After treatment,WOMAC score and VAS score were all reduced significantly as compared with those before treatment in the two groups(P<0.01).The scores in the treatment group were better than the control group(P<0.01).After treatment,the improvements in serum inflammatory factors were different significantly as compared with those before treatment in the two groups(P<0.05)and the results in the treatment group were better than the control group(P<0.05).Conclusion The combined treatment with bushen tongluo method and Chinese herbal fumigation relieves the clinical symptoms,improves knee joint function and the levels of inflammatory factors in the patients with KOA and it is advantageous in its safety.Hence,this therapy deserves to be promoted in clinical practice.