解毒活血法防治冠心病PCI术后再狭窄的研究进展

Research Progress of Prevention and Treatment of Restenosis after Coronary Heart Disease PCI by Jiedu Huoxue Method

冠心病是严重危害人类健康的心血管系统疾病,目前经皮冠状动脉介入治疗是冠心病血运重建的重要手段,但术后炎症反应引发的再狭窄仍是制约介入实施的一大瓶颈。中医认为“毒瘀互结”病机与支架术后炎症反应密切相关,解毒活血法可通过减轻炎症反应发挥防治血管内再狭窄的作用。本文从中西医对再狭窄的认识和防治、“毒瘀互结”是再狭窄形成的病理机制及解毒活血法在再狭窄防治中的应用等方面进行系统的分析和综述。

Coronary heart disease is a cardiovascular disease that seriously harms human health.At present,percutaneous coronary intervention is an important means for revascularization of coronary heart disease.However,postoperative restenosis caused by inflammatory reaction is still a major bottleneck restricting intervention.Chinese medicine believes that the pathogenesis of"drug and phlegm"is closely related to the inflammatory response after stenting.Detoxification and blood-activating methods can play a role in prevention and treatment of in-vascular restenosis by reducing the inflammatory response.This article systematically analyzes and summarizes the understanding and prevention of restenosis,the pathogenesis of restenosis and the application of detoxification and blood circulation in the prevention and treatment of restenosis.