老年社区获得性肺炎中D二聚体、C反应蛋白、血沉检测的临床意义

Clinical Significance of Detection of D-dimer,C-reactive protein and Erythrocyte Sedimentation Rate in Elderly Community Acquired Pneumonia

目的探讨血浆D二聚体(D-D)、C反应蛋白(CRP)和血沉(ESR)水平与老年社区获得性肺炎(CAP)严重程度的关系。方法收集130例老年CAP患者的临床资料,按不同的病情严重程度评分标准对患者进行分组,分别测定患者血浆D-D、CRP、ESR水平,分析其在不同分组间的差异。结果不同肺炎严重度指数(PSI)分级间、不同CURB-65分组间D-D、CRP水平比较差异均有统计学意义(P<0.05),重症肺炎组D-D、CRP水平均显著高于非重症肺炎组(P<0.01)。ESR水平在以上不同分组间比较差异均无统计学意义(P>0.05)。血浆D-D与CRP水平显著相关(r=0.368,P<0.01)。结论血浆CRP、D-D与CAP的严重程度有一定的相关性。

Objective To investigate the relationship between plasma D-dimer(D-D),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)level and the severity of community-acquired pneumonia(CAP)in the elderly.Methods The clinical data of 130 elderly patients with CAP were collected.The patients were divided according to different severity criteria.The plasma D-D,CRP and ESR were measured and the differences among different groups were analyzed.Results There were significant differences in D-D and CRP levels between different pneumonia severity index(PSI)grades and between different CURB-65 groups(P<0.05).D-D and CRP levels in severe pneumonia group was significantly higher than non-severe pneumonia group(P<0.01).There was no significant difference in the ESR between the above groups(P>0.05).Plasma D-D was significantly associated with CRP levels(r=0.368,P<0.01).Conclusion There is a certain correlation between plasma CRP and D-D levels and the severity of CAP,which can be used as an indicator to judge the patient’s condition.