不同严重程度获得性肺炎患者凝血及纤溶相关指标检测结果分析

Analysis of Coagulation and Fibrinolysis Related Indicators in Patients with Acquired Pneumonia of Different Severity

目的分析不同严重程度获得性肺炎患者凝血指标和纤溶指标的检测结果。方法选取2018年3月至2019年4月期间在我院就诊的获得性肺炎患者176例,按照其病情严重程度将其分为高危组(35例)、中危组(55例)和低危组(86例)。采集176例患者的清晨空腹静脉血作为检验样本,分别对其进行凝血检测和纤溶检测,对比分析三组患者的凝血检测指标和纤溶检测指标变化情况。结果患者的AT、BPC、TT等凝血指标检测结果,从低到高依次为高危组、中危组、低危组,且每两组之间的组间比较差异均具有统计学意义(P<0.05)。患者的aPTT检测结果,从低到高依次为低危组、中危组、高危组,每两组之间的组间比较差异均具有统计学意义(P<0.05)。患者的Fbg、PT检测结果,三组水平相当,每两组之间的组间比较差异均不具有统计学意义(P>0.05)。患者的D-D、FDPs、t-PA、PAI-1、纤溶指标检测结果,从高到低依次为高危组、中危组、低危组,且每两组之间的组间比较差异均具有统计学意义(P<0.05)。结论社区获得性肺炎患者的AT、BPC、TT、aPTT等凝血指标及D-D、FDPs、t-PA、PAI-1、纤溶指标会发生异常变化,且随着其肺炎病情的严重程度的加重,以上各项指标的异常程度也明显增大。

Objective To analyze the results of coagulation and fibrinolysis in patients with acquired pneumonia of different severity.Methods 176 patients with community acquired pneumonia in our hospital from March 2018 to April 2019 were selected and divided into high risk group(35 cases),medium risk group(55 cases)and low risk group(86 cases)according to the severity of the disease.The fasting venous blood of 176 patients in the morning was collected as test samples.The coagulation and fibrinolysis were detected respectively.The changes of coagulation and fibrinolysis were compared among the three groups.Results The results of AT,BPC,TT and other coagulation indicators were in the high-risk group,the middle-risk group and the low-risk group from low to high,and the difference between the two groups was statistically significant(P<0.05).The aPTT test results of the patients from low to high were low-risk group,medium-risk group and high-risk group.The difference between the two groups was statistically significant(P<0.05).The results of Fbg and PT were similar in the three groups,and there was no significant difference between the two groups(P>0.05).The results of D-D,FDPs,t-PA,PAI-1,indicators were in the order of high-risk group,medium-risk group and low-risk group from high to low,and the difference between the two groups was statistically significant(P<0.05).Conclusion Coagulation indexes such as AT,BPC,TT,aPTT and fibrinolysis indexes such as D-D,FDPs,t-PA,PAI-1 may change abnormally in patients with acquired pneumonia,and the abnormal degree of the above indexes will also increase with the aggravation of the severity of pneumonia.