摘要
SET8(PR-set7、SETD8或KMT5A)是目前发现的唯一的组蛋白H4赖氨酸20单甲基转移酶,调节细胞周期的正常运转。SET8的异常表达能够促进肿瘤的增殖、侵袭和转移,可预测肿瘤的不良预后。同时,SET8还能影响肿瘤的能量代谢,促进肿瘤的发生、发展。现就SET8在肿瘤中的作用予以综述,探讨其调控机制及靶向治疗的前景。
SET8(PR-set7,SETD8 or KMT5A)is the only histone monomethylation transferase targeting H4K20,which is an important regulator of cell cycle.The abnormal transcription of SET8 leads to tumorigenesis,invasion and metastasis,and is associated with the poor prognosis.Meanwhile,the abnormal transcription of SET8 also regulates energetic metabolism in cancer to promote tumor progression.This review described the function of SET8 in tumor.And only when we know the mechanism deeply,can we use it to guide tumor diagnosis.New medicine targeting SET8 for tumor therapy is anticipated.
作者
申雪芳
花晴(综述)
许平波(审校)
SHEN Xuefang;HUA Qing;XU Pingbo(Department of Anesthesiology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China)
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2019年第8期595-598,共4页
China Oncology
基金
国家自然科学基金资助项目（N5FC81471852）
关键词
SET8
肿瘤
增殖
转移
SET8
Tumor
Proliferation
Metastasis
