纳米氧化锌的制备及抗菌性能研究

Preparation and Antibacterial Properties of Zinc Oxide Nanoparticles

目的研究以乙酸锌和氢氧化钠为原料,利用水热合成法制备纳米氧化锌的最佳工艺条件及抗菌性能。方法以纳米氧化锌的粒径和形貌为评价指标,讨论合成条件对产物的影响;基于单因素设计响应面实验,以抑菌圈直径为响应值,分析抑菌效果较好的纳米氧化锌的制备条件。结果在水热温度为111.14℃,反应时间为10 h,乙酸锌浓度为0.02 mol/L时制备的纳米氧化锌的抗菌效果最好,大肠杆菌的抑菌圈直径为(17.265±0.011)mm。结论水热温度、水热时间和前驱体浓度会影响纳米氧化锌的粒径和形貌;水热温度和前驱体浓度是影响纳米氧化锌抑菌性的显著因素,水热时间是非显著因素。

The work aims to study the optimum technological conditions and antibacterial properties of nano-ZnO particles prepared by hydrothermal synthesis,with zinc acetate and sodium hydroxide as raw materials.The particle size and morphology of nano-ZnO particles were used as evaluation indicators to discuss the influence of synthesis conditions on the product.Based on the single-factor design response surface experiment,with the diameter of the inhibition zone as the response value,the preparation conditions of nano-ZnO particles with good antibacterial effect were analyzed.The nano-ZnO particles prepared under the following conditions had the best antibacterial effect:the hydrothermal temperature of 111.14℃,the reaction time of 10 h,and the concentration of zinc acetate of 0.02 mol/L.The inhibition zone diameter of escherichia coli was(17.265±0.011)mm.The hydrothermal temperature,hydrothermal time and precursor concentration affect the particle size and morphology of nano-ZnO particles.Hydrothermal temperature and precursor concentration are significant factors affecting the antibacterial activity of nano-ZnO particles.Hydrothermal time is not a significant factor.