银川市妇幼保健院11055例孕妇血清维生素A、E水平分析

Analysis of Serum Vitamin A and E Levels in 11055 Pregnant Women in Yinchuan Maternal and Child Health Care Hospital

目的通过检测分析银川市妇幼保健院产前检查的正常妊娠孕妇血清维生素A、E浓度,了解孕期血清维生素A、E水平状况。方法收集2015年5月-2017年7月于银川市妇幼保健院产前检查的孕妇血清样本,妊娠中期(14~27+6周)3814例及晚期(28周后)7241例,共计11055例,采用高效液相色谱法定量测定血清维生素A、E浓度。结果妊娠中、晚期血清维生素A平均水平分别为(0.48±0.11)mg·L-1、(0.42±0.13)mg·L-1,总体异常率为15.37%,其中缺乏率为12.39%,过量率为2.98%。妊娠中、晚期血清维生素E平均水平分别为(14.76±3.29)mg·L-1、(15.49±4.13)mg·L-1,总体异常率为9.85%,其中缺乏率为0.06%,过量率为9.79%。结论银川市妇幼保健院院产检的孕妇妊娠中晚期血清维生素A、E平均水平处于正常范围,维生素A的异常率以缺乏为主要表现,维生素E的异常率以过量为主要表现,重视孕期维生素A、E的监测,有利于孕妇个体化合理正确补充。

Objective The serum vitamin A and E levels of normal pregnant women examined by Yinchuan Maternal and Child Health Hospital were detected and analyzed to understand the status of serum vitamin A and E levels during pregnancy.Methods Serum samples were collected from a total of 11055 pregnant women receiving prenatal examination in Yinchuan Maternity and Child Health Care Hospital from May 2015 to July 2017,including 3814 cases in the second trimester(14~27+6 weeks)and 7241 cases in the third trimester(beyond 28 weeks).The concentration of serum vitamin A and vitamin E was determined using HPLC.Results The mean levels of serum vitamin A in the second and third trimesters were(0.48±0.11)mg·L-1 and(0.42±0.13)mg·L-1 respectively.The overall vitamin A abnormality rate was 15.37%;the deficiency rate was 12.39%,and the excess rate was 2.98%.The mean levels of serum vitamin E in the second and third trimesters were(14.76±3.29)mg·L-1 and(15.49±4.13)mg·L-1 respectively.The overall vitamin E abnormality rate was 9.85%;the deficiency rate was 0.06%,and the excess rate was 9.79%.Conclusions Among pregnant women receiving prenatal examination in Yinchuan Maternity and Child Health Care Hospital,serum vitamin A and vitamin E are generally within the normal range.The abnormal rate of vitamin A is predominantly deficiency,whereas the abnormal rate of vitamin E is mainly manifested by excess.Attention to the monitoring of vitamin A and E during pregnancy is conducive to individualized,rational and correct supplementation of pregnant women.