宫颈上皮内瘤变患者LEEP术后宫颈粘连的相关因素分析

Relevant Factors Analysis of Cervical Adhesion in Patients with Cervical Intraepithelial Neoplasia after LEEP

目的探讨影响宫颈上皮内瘤变(CIN)患者宫颈环形电切术(LEEP)后宫颈粘连的因素。方法选择2015年10月至2017年12月在我院例接受LEEP治疗的宫颈CIN的患者,依据有无宫颈粘连分为观察组(发生宫颈粘连患者53例)和对照组(无宫颈粘连患者100例)。记录手术时间、出血量、并发症情况及术后随访情况,进行多因素Logistic回归分析。结果观察组患者年龄[(37.4±8.72)岁]、切除深度≥15mm(62.26%)、术中出血(15.09%)及术后感染(16.98%)发生率均显著均高于对照组(P<0.05);Logistic回归显示年龄(偏大)、切除深度(≥15mm)和术后感染是宫颈粘连的危险因素(P<0.05)。结论年龄、切除深度、术后感染是CIN患者LEEP术后发生宫颈粘连的危险因素,在临床上注意规范LEEP操作、积极预防感染能够有效较少宫颈粘连的风险,提高预后。

Objective To investigate the factors affecting cervical adhesion in patients with cervical intraepithelial neoplasia(CIN)after loop electrosurgical excision procedure(LEEP).Methods Patients with CIN treated with LEEP in our hospital from October 2015 to December 2017 were selected.They were divided into observation group(53 cases of cervical adhesion)and control group(100 cases without cervical adhesion)according to cervical adhesion.The operation time,bleeding volume,complications and postoperative follow-up was recorded,and multivariate logistic regression analysis was performed.Results The ratio of age[(37.4±8.72)years old]and resection depth(≥15mm)(62.26%),the incidence of intraoperative bleeding(15.09%)and postoperative infection(16.98%)in observation group was significantly higher than those in the control group(P<0.05).Logistic regression showed that age(older),resection depth(≥15mm)and postoperative infection were risk factors for cervical adhesion(P<0.05).Conclusion Age,resection depth and postoperative infection are risk factors for cervical adhesion in patients with CIN after LEEP.In clinical practice,attention should be paid to standardizing LEEP operation,and active prevention of infection can effectively reduce the risk of cervical adhesion and improve the prognosis.