奥贝胆酸的研究进展

Research progress of obeticholic acid

奥贝胆酸是一种新型选择性FXR激动剂,在调节胆汁酸代谢及糖脂代谢中发挥着重要的作用,是原发性胆汁性肝硬化以及非酒精性脂肪肝的新型候选药物。奥贝胆酸可通过抑制纤维化进程和抑制炎性反应过程从而缓解疾病。

Obeticholic acid is a novel selective FXR agonist which plays an important role in regulating bile acid metabolism,as well as glucose and lipid metabolism.It is a new drug candidate for primary biliary cirrhosis and non-alcoholic fatty liver disease.A series of studies have shown that obeticholic acid can alleviate the disease by inhibiting the progression of fibrosis and inhibiting the inflammatory process.