养正合剂改善乳腺癌术后化疗者不适及对患者细胞因子、红细胞免疫的影响

Yangzheng mixture improves the discomfort of postoperative chemotherapy in patients with breast cancer and its immunity to cytokines and red blood cells

目的:观察养正合剂改善乳腺癌术后化疗者机体不适感及对患者细胞因子、红细胞免疫状态的影响。方法:选取乳腺癌术后化疗者120例,采用随机数字表法分为对照组和观察组,每组各60例。对照组一般支持治疗联合康艾注射液、观察组一般支持治疗联合养正合剂。观察和比较两组患者化疗前后机体不适症状及血常规、细胞因子、红细胞免疫状态。结果:化疗后,观察组恶心呕吐、食欲下降评分高于化疗前,对照组疲乏、恶心呕吐、呼吸困难、失眠、食欲下降、腹泻评分高于化疗前;观察组不适症状评分低于对照组,差异有统计学意义(P<0.05)。化疗后,观察组WBC计数低于化疗前,对照组WBC计数低于化疗前,TNF-α、IL-6水平高于化疗前;观察组WBC计数高于对照组,TNF-α、IL-6水平低于对照组,差异均有统计学意义(P<0.05)。化疗后,观察组FEER水平低于化疗前、FEIR和RBC-ICR水平高于化疗前,但差异无统计学意义(P>0.05);对照组差异有统计学意义(P<0.05)。且观察组FEER水平高于对照组,FEIR和RBC-ICR水平低于对照组,差异均有统计学意义(P<0.05)。结论:养正合剂通过减少乳腺癌术后化疗者机体炎性细胞因子大量释放、改善红细胞免疫状态,利于减轻患者术后化疗者疲乏无力等机体不适感且效果显著、作用确切,不失为一种有效的联合干预方法。

Objective:To observe the effect of Yangzheng mixture on the body discomfort and the immune status of cytokines and erythrocytes in patients with breast cancer after chemotherapy.Methods:120 patients with postoperative chemotherapy for breast cancer were selected and divided into control group and observation group by random number table method,60 cases in each group.The control group generally supported the treatment combined with Kang,ai injection,and the observation group generally supported the treatment of the combination of Yangzheng mixture.The symptoms and blood routine,cytokines and erythrocyte immune status of the two groups were observed and compared before and after chemotherapy.Results:After chemotherapy,the nausea and vomiting and appetite decline scores in the observation group were higher than those before chemotherapy.The control group was fatigued,nausea and vomiting,dyspnea,insomnia,loss of appetite,and diarrhea scores before chemotherapy.The discomfort score of the observation group was lower than that of the control group.The difference was statistically significant(P<0.05).After chemotherapy,the WBC count in the observation group was lower than that before chemotherapy.The WBC count of the control group was lower than that before chemotherapy,and the levels of TNF-αand IL-6 were higher than those before chemotherapy.The WBC count of the observation group was higher than that of the control group,TNF-α,IL-6.The level was lower than the control group,and the difference was statistically significant(P<0.05).After chemotherapy,the FEER level in the observation group was lower than that before chemotherapy,FEIR and RBC-ICR levels were higher than those before chemotherapy,but the difference was not statistically significant(P>0.05).The difference in the control group was statistically significant(P<0.05).The FEER level in the observation group was higher than that in the control group,and the FEIR and RBC-ICR levels were lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:Yangzheng mixture can reduce the body's inflammatory cytokine release and improve the red blood cell immune status after chemotherapy,which is beneficial to alleviate the body discomfort such as fatigue and weakness of postoperative chemotherapy,and the effect is remarkable and effective.