坏死性软组织感染的诊治

Diagnosis and treatment of necrotic soft tissue infection

坏死性软组织感染(NSTI)是一类因细菌感染导致的皮肤及皮下软组织大面积坏死的疾病。首先,本文探讨了NSTI的流行病学、病因及其发病机制,并总结了其主要的致病微生物与分型。鉴于NSTI具有进展迅速和局部组织破坏严重的特点,随后本文重点描述了该疾病的临床表现并分析了其诊断要点,以提高临床医师对该疾病的警惕性。最后,本文概述了目前主要的治疗策略,包括彻底清创引流,充分复苏和应用敏感抗生素等。

Necrotizing soft tissue infection(NSTI)is a kind of disease characterized by skin and subcutaneous soft tissue necrosis caused by bacterial infection.Firstly,the epidemiology,etiology and pathogenesis of NSTI are discussed in this paper and its major pathogenic microorganisms and classification are also summarized.Knowing the characteristics of rapid progress and serious local tissue destruction of NSTI,then we mainly describe the clinical manifestations and analyze the key points of diagnosis of NSTI in order to improve the alertness of clinicians to this kind of disease.Finally,this paper summarizes the current strategies for NSTI treatment,including thorough debridement and drainage,adequate resuscitation and the use of sensitive antibiotics.