干细胞抑制病理性瘢痕形成的研究进展

Research progress on stem cell therapy for pathological skin scars

病理性瘢痕当前临床治疗方法的效果尚不理想,干细胞因其自我更新和分化能力有望给治疗带来新思路,本文介绍了病理性瘢痕干细胞疗法中常见的不同来源的细胞类型,包括各类间充质干细胞、人羊膜上皮细胞、胚胎干细胞和诱导性多能干细胞,以及各类干细胞用于临床治疗的优、缺点,指出了干细胞疗法的关键突破点在于分泌蛋白的调控、干细胞使用的时机、干性的传递与维持、为患者选择合适的干细胞群等,为病理性瘢痕干细胞疗法的发展方向提供了参考。

The current clinical treatment effect of hypertrophic scar is not satisfactory.Stem cells are expected to bring new ideas to treatment because of their ability to self-renew and differentiate.This article introduces some scar stem cells of different sources and their advantages and disadvantages,including various mesenchymal stem cells,human amniotic epithelial cells,embryonic stem cells and induced pluripotent stem cells etc.Besides,this article points out that the key points of breakthrough in stem cell therapy are the regulation of secreted protein,the proper using time of stem cells,the transmission and maintenance of stemness,and the selection of appropriate stem cell population for patients,etc.and provide a reference for the development of pathological scar stem cell therapy.