血液相关指标与弥漫大B细胞淋巴瘤预后关系分析

A Prognosis Analysis of Blood-related Indicator with Diffuse Large B Cell Lymphoma

目的分析弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)相关临床资料,探讨常见血液相关指标对DLBCL预后的指导意义。方法回顾性分析2011年1月至2017年12月世纪坛医院收治的45例初治DLBCL患者临床资料,生存分析应用Kaplan-Meier法,单因素分析应用Log-rank检验,多因素分析应用Cox回归模型。结果单因素分析结果显示:血小板计数(PLT)、Hans分型、血红蛋白水平(HGB)、血清白蛋白(ALB)水平差异具有统计学意义(P<0.05),与预后有关。多因素分析结果显示:PLT、Han分型差异具有统计学意义,可作为DLBCL独立预后因素。性别、年龄、初诊原发部位、红细胞计数(RBC)、白细胞计数(WBC)、中性粒细胞绝对值计数(Neu#)、淋巴细胞绝对值计数(Lym#)、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞绝对值计数比值(PLR)、乳酸脱氢酶(LDH)、总蛋白(TP)差异均无统计学意义。结论PLT≤209×10^9/L,Hans分型为非生发中心型,HGB≤100g/L,ALB<40g/L可能是DLBCL不良预后因素。PLT、Hans分型可作为DLBCL患者总生存期的独立影响因素。

Objective To analyze the clinical characteristics of the patients with diffuse large B-cell lymphoma(DLBCL),and evaluate the significance of blood-related indicators in the prognosis of DLBCL.Methods The clinical data of forty-five patients who were newly diagnosed DLBCL in the Beijing Shijitan Hospital from January,2011 to December,2017 was collected.Kaplan-Meier survival analysis,log-rank test and Cox regression model multivariate analysis were used to analyze the prognostic factors of DLBCL patients.Results Univariate analysis showed that PLT,Hans immunological subtypes,HGB and ALB were significantly related to the prognosis of DLBCL(P<0.05),while gender,age,invasive site of initial diagnosis,RBC,WBC,Neu#,Lym#,NLR,PLR,LDH and TP were not related to the prognosis of DLBCL(P>0.05).Multivariate analysis showed PLT,Hans immunological subtypes were independent prognostic factors of DLBCL(P<0.05).Conclusion PLT≤209×10^9/L,Immuno-phenotype of non-germinal center subtype,HGB≤100g/L and ALB<40g/L are the adverse prognostic factors of prognosis in patients with DLBCL.PLT and Hans immunological subtypes are the independent risk factors of prognosis in DLBCL patients.