不同状态下系统性红斑狼疮与补体的相关性分析

The Clinical Value of Alexin C3 and C4 on Systemic Lupus ErythematosusPatients in Different States

目的观察不同状态下系统性红斑狼疮(systemic lupus erythematosus,SLE)患者补体C3、C4水平变化并探讨其临床意义。方法选取326例系统性红斑狼疮患者作为本次研究对象。按照抗双链DNA(dsDNA)抗体阴阳性分为dsDNA阴性及阳性组,按照抗核抗体(ANA)核型分为阴性、均质型、斑点型、核仁型及其他型组。比较两种分组方式下C3、C4的结果。结果dsDNA阳性患者C3、C4水平均低于阴性患者,差异具有统计学意义(P<0.05);ANA为均质型、斑点型及其他型患者C3、C4水平均低于ANA阴性组及核仁型组患者,差异具有统计学意义(P<0.05)。结论不同状态下系统性红斑狼疮患者补体C3、C4水平存在差异,联合检测补体C3、C4有助于对SLE病情活动性及自身抗体类型作出判断。

Objective To evaluate the changes of alexin C3 and C4 levels in patients with systemic lupus erythematosus(SLE)in different states.Methods A total of 326 subjects with systemic lupus erythematosus were enrolled for the study.Patients were classified into the dsDNA positive group and dsDNA negative group.And patients were divided into the ANA negative group,homogeneous type group,speckled type group,nucleolar type group and other groups depending on their ANA fluorescence karyotype.Results The levels of C3 and C4 in patients with positive dsDNA were lower than those in patients with negative dsDNA,and the difference was statistically significant(P<0.05).The levels of C3 and C4 in the ANA homogenous type group,speckled type group and other groups were lower than those in the ANA negative group,and also lower than those in the ANA nucleolar type group,with statistically significant differences(P<0.05).Conclusion There are differences in the levels of alexin C3 and C4 in patients with systemic lupus erythematosus in different states.Combined detection of alexin C3 and C4 could help to predict SLE disease activity.