含典型氟-氢邻近与远程耦合的混合物的核磁共振氢谱示例

Examples of ~1H NMR Spectra of Mixture of Compounds Containing Vicinal and Long-Range Fluorine-Proton Coupling

设计合成了两组含氟的四取代苯化合物,苯环上的两个氢分别与F构成邻位和间位。所得化合物经核磁共振氢谱确认后,均为混合物。两组混合物芳香区氢谱简单,但又极具典型性。每个化合物苯环上的两个质子的氢谱均清晰体现了氟对其的邻近及远程耦合。此外两组共混物,一组有谱图重叠,一组没有,也可以作为既典型又简洁的共混物氢谱示例。

Two serials of tetrasubstituted benzene compounds containing fluoro group were designed and synthesized.The other three substitutes are sequentially the para,meta,and ortho to fluoro group.The obtained compounds were all mixtures as confirmed by 1H NMR spectroscopies.The spectra clearly show the proximity and remote interaction between fluorine atom and hydrogen atom.In addition,the two spectra,one showing the overlapping peaks,one not,can be used as the simple and typical example of 1H NMR spectra of mixtures.