完整结肠系膜切除术治疗左半结肠癌的效果及安全性分析

Effect and safety analysis of complete mesorectal excision in the treatment of left colon cancer

目的探讨完整肠系膜切除术(CME)在治疗左半结肠癌的临床疗效和安全性。方法选取2014年1月~2018年1月我院收治的62例左半结肠癌患者,随机分为对照组(30例)和观察组(32例)。对照组予以传统根治术治疗;观察组予以CME治疗。观察两组的临床疗效、血清miR-101、miRNA10a表达水平变化及术后机体情况。结果观察组术中出血量明显少于对照组(P<0.05),拔管时间、术后肛门排气时间明显短于对照组(P<0.05),平均淋巴结清扫数量明显高于对照组(P<0.05);观察组血清miR-101、miRNA10a表达水平明显高于对照组(P<0.05);观察组术后并发症发生率、局部复发率明显低于对照组,差异有统计学意义(P<0.05)。结论CME治疗左半结肠癌可明显减少患者术中出血量,提高淋巴结清扫数量,患者预后更佳,值得临床推广。

Objective To investigate the clinical efficacy and safety of complete mesenteric resection(CME)in the treatment of left colon cancer.Methods Sixty-two patients with left colon cancer from January 2014 to January 2018 were selected and randomly divided into control group(30 cases)and observation group(32 cases).The control group was treated with traditional radical surgery and the observation group was treated with CME.The clinical efficacy,serum miR-101,miRNA10a levels and postoperative body conditions of the two groups were observed.Results The intraoperative blood loss of the observation group was significantly lower than that of the control group(P<0.05).The extubation time and postoperative anal exhaust time of the observation group were significantly shorter than that of the control group(P<0.05),and the average lymph node dissection was significantly higher than that of the control group(P<0.05).The serum levels of miR-101 and miRNA10a in the observation group were significantly higher than those in the control group(P<0.05).The incidence of postoperative complications and local recurrence rate in the observation group was significantly lower than that in the control group(P<0.05).Conclusion CME for left colon cancer can significantly reduce the amount of intraoperative blood loss,increase the number of lymph node dissection,and better prognosis.It is worthy of clinical promotion.