摘要
目的分析早孕者(孕4~12周)血清人绒毛膜促性腺激素(HCG)、雌二醇(E2)水平变化情况及其预测早期妊娠结局的价值。方法回顾性分析2017年11月~2018年10月于我院检查的47例早孕者临床资料,根据孕12周超声检查结果分为正常妊娠组(29例)、流产组(13例)、异位妊娠组(5例)。将排卵日设为0 d,将排卵后15~17 d作为首次检查时间,第2次检查间隔2~3 d,第3次检查间隔7 d,第4次检查间隔10 d以上;采用化学发光法测定血清E2、HCG水平。观察三组间隔2~3、7、≥10 d时的HCG及E2水平变化。结果流产组、异位妊娠组不同间隔时间(2~3 d、7 d、≥10 d)的HCG水平低于正常妊娠组,流产组不同间隔时间(2~3 d、7 d、≥10 d)的HCG水平高于异位妊娠组,差异有统计学意义(P<0.05);异位妊娠组的HCG水平呈下降趋势,正常妊娠组、流产组HCG水平呈上升趋势,各组间比较差异有统计学意义(P<0.05);异位妊娠组、流产组不同间隔时间(2~3 d、7 d、≥10 d)的E2水平低于正常妊娠组,异位妊娠组不同间隔时间(2~3 d、7 d、≥10 d)的E2水平高于流产组,差异有统计学意义(P<0.05);正常妊娠组的E2水平呈上升趋势,流产组的E2水平呈下降趋势,异位妊娠组E2水平先上升、后下降,各组间比较差异有统计学意义(P<0.05)。结论动态监测血清HCG及E2水平利于预测早期妊娠结局,可为早期妊娠结局诊治提供指导。
Objective To analyze the changes of serum human chorionic gonadotropin(HCG)and estradiol(E2)levels in early pregnancy women(pregnancy for 4-12 weeks)and the value of predicting early pregnancy outcomes.Methods The clinical data of 47 early pregnant women(4-12 weeks of pregnancy)examined in our hospital from November 2017 to October 2018 were retrospectively analyzed.According to the results of ultrasonic testing during 12-week pregnancy,they were divided into the normal pregnancy group(n=29),the abortion group(n=13),the ectopic pregnancy group(n=5).The ovulation day was set to 0 d,the first examination was 15-17 d after ovulation,the second examination was 2-3 d interval,the third examination was 7 d interval,and the fourth examination was more than 10 d interval.The levels of serum E2 and HCG were determined using chemiluminescence method.The changes of HCG and E2 levels were observed in the three groups at intervals of 2-3 d,7 d and≥10 d.Results The HCG levels in the abortion group and the ectopic pregnancy group at different intervals(2-3 d,7 d,≥10 d)were lower than those in the normal pregnancy group,the HCG levels in the abortion group at different intervals(2-3 d,7 d,≥10 d)were higher than those in the ectopic pregnancy group,the difference was statistically significant(P<0.05).In the ectopic pregnancy group,the HCG level showed a descending trend.However,the HCG levels in the normal pregnancy group and the abortion group displayed an upward trend,which were displayed statistical significance among inter-group comparisons(P<0.05).The level of E2 in the ectopic pregnancy group and the abortion group at different intervals(2-3 d,7 d,≥10 d)were lower than those in the normal pregnancy group,the level of E2 in the ectopic pregnancy group at different interval(2-3 d,7 d,≥10 d)were higher than those in the abortion group,the difference was statistically significant(P<0.05).The level of E2 in the normal pregnancy group showed a rising trend,while descending in the abortion group,but first rising and then descending in the ectopic pregnancy group,which were displayed statistical significance among inter-group comparisons(P<0.05).Conclusion Dynamic monitoring of serum HCG and E2 levels is beneficial to predicting early pregnancy outcomes,and can provide guidance for the diagnosis and treatment of early pregnancy outcomes.
作者
帅妹
黄云
廖花
岳林林
SHUAI Mei;HUANG Yun;LIAO Hua;YUE Lin-lin(Department of Reproduction and Genetics,Maternal and Child Health Hospital of Ganzhou City in Jiangxi Province,Ganzhou,341000,China)
出处
《中国当代医药》
2019年第26期85-87,100,共4页
China Modern Medicine
基金
江西省卫生计生委科技计划项目(20177268)
关键词
早期妊娠
妊娠结局
人绒毛膜促性腺激素
雌二醇
Early pregnancy
Pregnancy outcome
Human chorionic gonadotropin
Estradiol