血常规检验在地中海贫血诊断中的应用价值

Application value of blood routine test in the diagnosis of thalassemia

目的探讨血常规检验在地中海贫血诊断中的作用。方法选取我院2018年1~12月收治的100例贫血患者作为研究对象,对其临床资料进行回顾性分析,所有患者入院后均行血常规检测及传统的红细胞孵育渗透脆性试验,分别进行疾病诊断,所有患者最终均经分子生物学方法确诊。比较两组检验方法的诊断效能。结果在地中海贫血的诊断中,血常规检测的灵敏度、特异度、准确度、阴性预测值、阳性预测值均显著高于红细胞孵育渗透脆性试验,差异均有统计学意义(P<0.05)。结论血常规检验可用于地中海贫血的初步诊断,有较高的诊断灵敏度和阴性预测值,但确诊还需结合其他诊断技术。

Objective To investigate the role of blood routine tests in the diagnosis of thalassemia.Methods A total of 100 anemia patients admitted to our hospital from January to December 2018 were selected as the research object,the clinical data were retrospectively analyzed.All patients were diagnosed by routine blood test and traditional erythrocyte incubation osmotic fragility test after admission,and disease diagnosis was performed separately.All patients were finally diagnosed by molecular biological methods.The diagnostic performance of the two groups of test methods was compared.Results In the diagnosis of thalassemia,the sensitivity,specificity,accuracy,negative predictive value and positive predictive value of blood routine test were significantly higher than those of erythrocyte incubation osmotic fragility test,and the difference was statistically significant(P<0.05).Conclusion The routine blood test can be used for the initial diagnosis of thalassemia,it has high diagnostic sensitivity and negative predictive value,but it needs to be combined with other diagnostic techniques.