应用经颅微电流刺激治疗对青年失眠的临床疗效观察

Clinical observation of simple application of cranial electrotherapy stimulation on insomnia in young adults

目的观察应用经颅微电流刺激(CES)治疗青年人失眠的临床疗效,以及疗效持续时间。方法前瞻性研究,选取2018年度首都医科大学附属北京友谊医院收治的30例青年失眠患者,失眠时间≥1个月,至少每周3次,且并未采取药物干预。给予CES治疗每日30 min,每日1次,连续治疗4周。所有患者于治疗前后进行匹兹堡量表(PSQI)评估。比较干预前(T 0)、治疗开始第一周(T 1)、治疗开始第二周(T 2)、治疗开始第三周(T 3)、治疗开始第四周(T 4)各项PSQI评分及总分;比较治疗第4周与随访(治疗停止一月后)时各项PSQI评分及总分;比较治疗前与随访(治疗停止一月后)各项PSQI评分及总分。结果CES治疗干预1周后,受试者的PSQI总分开始下降(T 0:13.10±1.30分,T 1:11.03±1.56分,T 2:9.23±1.73分,T 3:8.27±1.60分;T 4:7.50±1.25分)且差异具有统计学意义(P<0.05);继续干预4周后,PSQI总分及各项分数均较干预前进一步下降(T 0:13.10±1.30分,T 4:7.50±1.25分),差异具有统计学意义(P<0.05);1个月后进行随访显示,所有受试者的各项PSQI评分及总分均较干预前显著降低,差异具有统计学意义(P<0.05)。CES干预过程中未见不良反应发生。结论应用CES治疗青年失眠有效,治疗停止后疗效持续时间至少一个月,且无不良反应,可作为首选治疗方法。

Objective To observe whether cranial electrotherapy stimulation(CES)was effective for insomnia in young adults and the duration of curative effect.Methods Prospective study,Thirty young patients with insomnia admitted to Beijing Friendship Hospital Capital Medical University in 2018 were selected.Insomnia lasted more than one month,at least three times a week,and no drug intervention was taken.All subjects take CES treatment for 30 minutes a day,once a day for four weeks.Pittsburgh Sleep Quality Index(PSQI)was evaluated before and after treatment per week.The PSQI scores and total scores were compared before intervention(T 0),the first week of treatment(T 1),the second week of treatment(T 2),the third week of treatment(T 3),and the fourth week of treatment(T 4);the PSQI scores and total scores were compared between the fourth week of treatment and the follow-up(one month after treatment stops);The PSQI scores and total scores were compared pre-treatment with follow-up(1 month after treatment stops).Results After the first week of treatment,the total scores of the PSQI decreased significantly compared with baseline(T 0:13.10±1.30,T 1:11.03±1.56,T 2:9.23±1.73,T 3:8.27±1.60,T 4:7.50±1.25),and the difference has statistical significance(P<0.05).After 4 weeks of continuous intervention,score of each item and the total scores of the PSQI were decreased further than the baseline(the total scores before treatment 13.10±1.30,after four weeks of treatment(7.50±1.25),and the difference has statistical significance(P<0.05).Follow-up after 1 month showed that all subjects'score of each item and total scores of the PSQI were significantly lower than those before intervention(P<0.05),the difference has statistical significance.No adverse reactions occurred during CES intervention.Conclusion Simple application of CES is effective and has no adverse reactions in treating insomnia in young adults,curative effect lasts for at least one month.It can be used as the first treatment intervention.