摘要
随着社会老龄化问题的加剧,老年痴呆症(AD)的患病率越来越高。AD与睡眠障碍存在关联,而睡眠障碍是AD的常见症状。AD可通过影响大脑视交叉上核导致松果体区褪黑素及其受体改变,并使胆碱能缺失,以及食欲素水平改变等机制导致睡眠障碍。本文就近年来AD导致睡眠障碍的特点及机制研究进展进行综述,以阐明AD与睡眠障碍的相关性,为防治AD和相关的睡眠障碍提供理论依据。
In recent years,the prevalence rate of Alzheimer’s disease(AD)has been increasing with the aggravation of social aging.AD is associated with sleep disorders,which are also common symptoms of AD.It has been shown that AD affects the suprachiasmatic nucleus and regulates melatonin and its receptors in the pineal region.In addition,AD can lead to the loss of cholinergic neurons and the alteration of orexin levels,resulting in sleep disorders.This article reviews the features and mechanisms of AD-caused sleep disorders to clarify the association between AD and sleep disorders and to provide a theoretical basis for the prevention and treatment of AD and sleep disorders.
作者
杨思敏
林倩
娄诗云
石静
杨美雯
洪芬芳
杨树龙
YANG Si-min;LIN Qian;LOU Shi-yun;SHI Jing;YANG Mei-wen;HONG Fen-fang;YANG Shu-long(Department of Physiology,College of Medicine of Nanchang University,Nanchang 330006,China;Department of Nurse,Nanchang University Hospital,Nanchang 330006,China;Experimental Teaching Center of Nanchang University,Nanchang 330031,China)
出处
《南昌大学学报（医学版）》
CAS
2019年第4期88-91,共4页
Journal of Nanchang University：Medical Sciences
基金
国家自然科学基金项目(81660751、81660151、81260504)
江西省重点研发计划项目(20161BBG70067)
江西省自然科学基金项目(20171BAB205085)
