三维细胞培养的研究进展

Advances in three-dimensional cell culture

三维细胞培养是近几年发展起来的一种新的细胞培养技术,该技术通过模拟细胞之间及细胞外基质信号传导的微环境,使细胞培养的状态更接近于生物体内。该技术有望成为现有的二维细胞培养和动物模型之间的桥梁,在疾病机制研究、药物高通量筛选及疫苗生产等领域发挥巨大作用。现就三维细胞培养在技术研究方面及应用领域中的进展进行了综述。

The technology of three-dimensional cell culture is a new cell culture technology developed in recent years.This technique can simulate the microenvironment between cells and extracellular matrix in the body,making the state of cell culture closer to the organism.The technology is expected to become a bridge between the existing two dimensional cell culture and animal models,and plays a great role in the research of disease mechanism,high throughput drug screening and vaccine production.The progress of 3D cell culture in technology and application are reviewed.