术后深静脉血栓与卵巢癌预后的相关性分析

The correlation between postoperative deep venous thrombosis and prognosis of ovarian cancer

目的:探讨卵巢癌术后深静脉血栓(DVT)对卵巢癌患者无病生存时间(DFS)的影响。方法:回顾分析2009年至2014年于华中科技大学同济医学院附属同济医院初诊为卵巢癌并行手术治疗的103例患者的临床资料。采用独立样本T检验比较卵巢癌术后并发深静脉血栓和未发深静脉血栓组卵巢癌患者的临床病理特征。采用单因素和多因素Cox回归分析影响卵巢癌术后无病生存时间(DFS)的独立因素;绘制受试者工作特征(ROC)曲线,分析术后深静脉血栓对卵巢癌DFS的预测能力,并确定最佳临界值;采用Kaplan-Meier曲线分析法,对卵巢癌患者进行生存分析。结果:103例患者中,DVT组25例,无DVT组78例。多因素分析提示,年龄、体重指数(BMI)、手术病理分期及是否术后并发DVT(P<0.05)与卵巢癌的DFS相关。DVT组和无DVT组卵巢癌患者的中位DFS比较,差异有统计学意义(P=0.03)。结论:卵巢癌患者术后合并DVT是一项重要的不良预后因素;是否发生DVT可作为卵巢癌患者DFS的独立预测指标,可与年龄、BMI共同预测患者的预后。

Objective:To investigate the correlation between DVT and DFS among patients with ovarian cancer.Methods:Clinical and pathological datas of 103 patients with ovarian cancer who underwent surgical resection in Tongji hospital from 2009 to 2014 were analyzed.The characteristic of two groups with or without DVT was analyzed.Univariate and multivariate analyses were performed to evaluate the clinical factors affecting DFS in ovarian cancer patients.The ROC curve of DVT predicting the patients'DFS was drawn.The DFS between the DVT(-)and DVT(+)groups was compared statistically.Results:Of 103 patients,25 had DVT while 78 had not.Age,BMI,stage and DVT were valuable factors to predict DFS(P<0.05).The DFS of patients with DVT was significant shorter than patients without DVT when compared statistically(P=0.03).Conclusions:The occurrence of DVT after surgery is an adverse prognostic factor for patients.DVT can be used as a predictive factor for DFS in the initial treatment of ovarian cancer.