MicroRNA-802和RAB23在前列腺癌中的表达水平及临床意义

Expression level of microRNA-802 and RAB23 in prostate cancer and its Clinical significance

目的探讨micro RNA-802(mi R-802)和RAB23在前列腺癌中的表达水平及临床意义。方法选取在海南省第三人民医院泌尿外科手术切除的前列腺癌标本60例,并选取其相对应癌旁组织作为对照,用免疫组织化学检测mi R-802和RAB23的表达水平,分析mi R-802和RAB23表达水平与前列腺癌患者临床病理参数间的关系及与前列腺癌患者预后。结果 miR-802和RAB23在前列腺癌组织中的阳性率分别为73.33%和70.00%,高于癌旁组织中的33.33%和28.33%(P <0.05)。mi R-802和RAB23表达水平与年龄和术前PSA无关(P>0.05);与Gleason评分相关,评分越高,表达率越低(P<0.05);与病理分期相关,表达高则病理分期早(P <0.05)。mi R-802和RAB23表达水平阴性组3年生存率及生存期均高于mi R-802和RAB23表达水平阳性组(P<0.05)。结论 miR-802和RAB23 mRNA在前列腺癌组织中的表达阳性率高于癌旁组织,阴性表达能获得较好的预后。

Objective To investigate expression level of miR-802 and RAB23 in prostate cancer and its clinical significance.Methods Totally 60 cases of prostate cancer tissues were selected and their adjacent tissues were control group.Immunohistochemistry was used to detect the expression of miR-802 and RAB23.Then the relationship between the expression of miR-802 and RAB23 and the clinicopathological parameters was analyzed,as did the prognosis of prostate cancer patients.Results The positive rates of miR-802 and RAB23 in prostate cancer tissues were 73.33%and 70.00%,respectively,which were higher than 33.33%and 28.33%in adjacent normal tissues(P<0.05).The expression levels of miR-802 and RAB23 were not significantly correlated with age and preoperative PSA(P>0.05),but were negatively correlated with the Gleason score(P<0.05)and pathological stage(P<0.05);the 3-year survival rate and survival time of the miR-802 and RAB23 negative expression groups were significantly higher than those of the miR-802 and RAB23 positive expression groups(P<0.05).Conclusions The expression levels of miR-802 and RAB23 mRNA are higher in prostate cancer tissues than those in adjacent normal tissues.The patients with negative expression of miR-802 and RAB23 can achieve better prognosis.