生长抑素联合乌司他丁对术后早期炎性肠梗阻患者血清炎症细胞因子的影响

Effect of Growth Inhibitors Combined with Urinastatin on Serum Inflammatory Cytokines in Patients with Early Postoperative Inflammatory Small Bowel Obstruction

目的探讨生长抑素联合乌司他丁对术后早期炎性肠梗阻患者血清炎症细胞因子的影响。方法选取2015年5月至2017年10月长沙医学院附属株洲市人民医院收治的50例术后早期炎性肠梗阻患者作为研究对象,并按照随机数表法将其随机分为试验组(25例)与对照组(25例),其中试验组患者在胃肠减压、抗感染、纠正水电解质紊乱等治疗的同时予以生长抑素联合乌司他丁治疗,对照组患者在胃肠减压、抗感染、纠正水电解质紊乱等治疗的同时予以生长抑素治疗,对比观察两组患者治疗前1 d及治疗第3、7天白细胞介素 6(IL 6)、白细胞介素 8(IL 8)、肿瘤坏死因子 α(TNF α)及超敏C 反应蛋白(hs CRP)等血清炎症细胞因子的变化情况。结果除治疗第3天,对照组患者hs CRP水平与治疗前对比无明显变化,P>0.05,差异无统计学意义外,其他各时间点两组患者血清IL 6、IL 8、TNF α及hs CRP水平组内两两对比,P均<0.05,差异具有统计学意义;治疗第3、7天两组患者血清IL 6、IL 8、TNF α及hs CRP水平组间对比,P均<0.05,差异具有统计学意义;治疗第7天,试验组患者的治疗总有效率为88.0%,对照组患者的治疗总有效率为68.0%,两组对比,P<0.05,差异具有统计学意义;治疗过程中,试验组患者不良反应发生率为8.0%,对照组患者不良反应发生率为32.0%,两组对比,P<0.05,差异具有统计学意义。结论生长抑素联合乌司他丁可减轻术后早期炎性肠梗阻患者的炎症反应,降低不良反应发生率,提高治疗效果。

Objective To investigate the effect of growth inhibitors combined with Urinastatin on the serum in flammatory cytokines in patients with early postoperative inflammatory small bowel obstruction(EPISBO).Methods Fifty patients with EPISBO admitted into Zhuzhou People’s Hospital Affiliated to Changsha Medical University between May 2015 and October 2017 were selected as subjects to be divided into an experiment group(25 cases)and a control group(25 ca ses)according to the random number table.Besides the treatments of decompressing the gastrointestine,fighting infection and correcting the disturbance of water and electrolyte,the patients in the experiment group were treated with growth inhibi tors combined with Urinastatin while the patients in the control group were treated simply with growth inhibitors.The chan ges of serum inflammatory cytokines including interleukin 6(IL 6),interleukin 8(IL 8),tumor necrosis factor α(TNF α)and hypersensitivity C reactive protein(hs CRP)were observed and compared between the two groups respective ly on one day before the treatment and on day 3 and 7 of the treatment.Results On day 3 of the treatment in the control group,the expression levels of hs CRP showed no statistically significant difference as compared with that before the treat ment,P>0.05.However,the pairwise comparison of the expression levels of serum IL 6,IL 8,TNF αand hs CRP at the other two time points within each of the two groups all showed statistically significant differences,all P<0.05.On day 3 and 7 of the treatment,the expression levels of serum IL 6,IL 8,TNF αand hs CRP were respectively compared between the two groups,and the results showed statistically significant differences,all P<0.05.On day 7 of the treatment,the total effective rate in the experiment group was 88.0%,which presented a statistically significant difference as compared with the corresponding 68.0%in the control group,P<0.05.During the course of treatment,the incidence of adverse reaction in the experiment group was 8.0%while that in the control group was 32.0%,between which the difference was statistically significant,P<0.05.Conclusion Growth inhibitors in combination with Urinastatin can alleviate the inflammatory reac tion of patients with EPISBO,decrease the incidence of adverse reactions and improve the therapeutic effect.