低氧运动介导miRNAs影响糖代谢:预防控制糖代谢异常的新认识

Hypoxia-mediated miRNAs affect glucose metabolism:new recognition of preventing and controlling glucose metabolism

背景:研究结果表明,miRNAs与肥胖和糖尿病关系密切,miRNAs可能成为糖尿病诊断和预后的潜在生物标志物。目的:通过综述miRNAs促进胰岛素的敏感性、控制胰岛素的合成以及调控胰岛素抵抗等在低氧运动方面的作用,探讨低氧运动介导miRNAs调控糖代谢的机制。方法:检索PubMed、CNKI和万方数据库等数据库关于低氧运动、糖代谢及miRNAs的相关研究,检索词为“低氧运动”“糖代谢”及“miRNAs”“Low oxygen movement”“Hypoxic exercise”“hypoxia-mediated”“Sugar metabolism”“Glucose metabolism”等。检索时限为2007年至2019年,按照纳入标准和排除标准对搜索文献进行筛选。结果与结论:研究表明,miRNAs调控靶基因的表达进而影响糖代谢的稳态,调节胰岛素信号的传导途径主要来自蛋白质级联表达的潜力。在低氧运动中miRNAs可以用作单个分子或联合治疗,整合有关miRNAs对胰岛素信号传导途径,用来开发新的miRNAs相关诊断和治疗方法,以望在不久的将来解决2型糖尿病的治疗问题。在低氧运动中miRNAs对糖代谢的影响机制不仅可以为科学降糖、控体质量提供理论依据,还可以将低氧运动作为糖代谢紊乱相关疾病的预防与控制的干预手段,从而为治疗糖代谢异常引起的疾病提供新的治疗途径。

BACKGROUND:miRNAs have been shown to be closely related to obesity and diabetes,which can be potential biomarkers for the diagnosis and prognosis of diabetes.OBJECTIVE:To review the roles of miRNAs in promoting insulin sensitivity,controlling insulin synthesis and regulating insulin resistance in hypoxic exercise,and to explore the mechanism of hypoxic exercise-mediated miRNAs in regulating glucose metabolism.METHODS:Relevant studies on hypoxic exercise glucose metabolism and miRNAs in PubMed,CNKI,WanFang databases were searched.The keywords were“miRNAs,low oxygen movement,hypoxic exercise,hypoxia-mediated,sugar metabolism,glucose metabolism”in English and Chinese,respectively.Relevant literatures published from 2007 to 2019 were searched and screened according to inclusion and exclusion criteria.RESULTS AND CONCLUSION:miRNAs have the potential to regulate the expression of major protein cascades in the insulin signaling pathway by regulating the expression of target genes and thereby affecting the homeostasis of glucose metabolism.miRNAs can also be used as single molecules or in combination therapy.There is an urgent need to integrate miRNAs into insulin signaling pathways and develop new miRNAs-related diagnostic and therapeutic approaches in hopes of addressing type 2 diabetes in the future.Studying the mechanism of the effects of miRNAs on glucose metabolism in hypoxic exercise can not only provide a theoretical basis for scientific hypoglycemic and body mass control,but also can be used as an intervention for the prevention and control of diseases related to glucose metabolism disorders.Diseases caused by abnormal glucose metabolism provide new therapeutic approaches.