浸润性三阴性乳腺癌的超声征象与Ki-67表达的关系研究

Correlations between ultrasonographic features and Ki-67 expression in invasive triple-negative breast cancer

目的分析浸润性三阴性乳腺癌的超声征象与癌组织Ki-67表达的关系。方法通过肿瘤基因图谱数据库分析浸润性三阴性乳腺癌组织中Ki-67的编码基因MKI67的表达及其与生存时间的关系。回顾性分析我院经病理确诊的72例浸润性三阴性乳腺癌患者的超声征象与Ki-67的免疫组织化学染色结果,分析其超声征象与Ki-67表达的关系。结果浸润性三阴性乳腺癌组织中MKI67mRNA水平较浸润性非三阴性乳腺癌高(11.80±0.11vs.10.70±0.05);浸润性三阴性乳腺癌组织中Ki-67高表达者,其总生存时间较Ki-67低表达者短[(34.9±5.1)个月vs.(40.3±4.5)个月],差异均有统计学意义(均P<0.05)。浸润性三阴性乳腺癌超声征象中,血流分级Ⅱ~Ⅲ级者Ki-67高表达的比例高于0~Ⅰ级者(63.2%vs.26.5%),差异有统计学意义(P<0.05);腋窝淋巴结转移者Ki-67高表达的比例高于无转移者(58.8%vs.34.2%),差异有统计学意义(P<0.05)。结论浸润性三阴性乳腺癌超声征象中血流分级及腋窝淋巴结与Ki-67表达水平有关。

Objective To analyze the relationship between the ultrasonographic features and Ki-67 expression in invasive triple-negative breast cancer(TNBC).Methods The expression of Ki-67 encoding gene MKI67 in invasive TNBC tissues and its relationship with survival time were analyzed by tumor gene mapping database.The ultrasonographic features of 72 patients with TNBC diagnosed by pathology and the immunohistochemical staining of Ki-67 were analyzed retrospectively.The relationship between ultrasound features and Ki-67 expression was analyzed.Results The level of MKI67 mRNA in TNBC tissues was higher than that in invasive non-TNBC(11.80±0.11 vs.10.70±0.05),and the overall survival time of Ki-67 high expression in TNBC tissues was shorter than that of Ki-67 low expression[(34.9±5.1)months vs.(40.3±4.5)months],the difference were statistically significant(both P<0.05).In the ultrasound features of TNBC patients,blood flow of gradeⅡ~Ⅲ had higher expression of Ki-67 than that of grade 0~Ⅰ(63.2%vs.26.5%),and TNBC with axillary lymph node metastasis had higher expression of Ki-67 than that without metastasis(58.8%vs.34.2%),and the difference were statistically significan(t both P<0.05).Conclusion Blood flow grading and axillary lymph nodes are associated with Ki-67 expression in TNBC patients.