调节性B细胞在炎症性肠病中的作用

Role of regulatory B cells in inflammatory bowel disease

调节性B细胞是具有免疫抑制功能的B细胞亚群,可以通过分泌IL-10、IL-35和TGF-β1抑制慢性炎症性疾病,使得患者对感染的炎症反应减弱和诱导免疫耐受,维持体内平衡。同时,CD1d信号分子或IL-10的缺失导致NK T细胞介导的肠道炎症增强,NF-kB的活化水平改变,以及Th1、Th17细胞的异常激活等可释放出各种炎症介质及免疫调节因子,进一步参与免疫反应,加重黏膜损伤。本文围绕调节性B细胞在炎症性肠病中的作用做相关总结,希望能为炎症性肠病的治疗提供研究新方向。

Regulatory B cells are subsets of B cells with immunosuppressive function.They can inhibit chronic inflammatory diseases by secreting IL-10,IL-35,and TGF-β1,which can weaken the inflammatory response to infection,induce immune tolerance,and maintain homeostasis.At the same time,the deletion of CD1d signal molecules or IL-10 leads to the enhancement of intestinal inflammation mediated by NK T cells;the change of activation level of NF-kB and the abnormal activation of Th1 and Th17 cells can release various inflammatory mediators and immunoregulatory factors,further participate in the immune response and aggravate mucosal injury.This article summarizes the role of regulatory B cells in inflammatory bowel disease,hoping to provide a new direction for the treatment of inflammatory bowel disease.