围绝经期RLS/PLM妇女肝郁积分与β-内啡肽、RLS积分的相关性

Correlation between Liver Depression Score,β-endorphine and RLS Score in Perimenopausal Women with RLS/PLM

目的通过观察围绝经期肝郁型不宁腿综合征/周期性腿动(RLS/PLM)妇女肝郁积分与β-内啡肽(β-EP)、RLS积分的相关研究,以期为围绝经期RLS/PLM肝郁妇女的临床诊疗提供部分客观依据。方法本研究纳入围绝经期RLS/PLM肝郁组37例,围绝经期RLS/PLM非肝郁组30例。比较2组β-EP、RLS积分的差异性,分析血清β-EP、肝郁积分和RLS积分的相关性。结果与非肝郁组比较,围绝经期RLS/PLM肝郁组血清β-EP明显下降(P<0.05),RLS积分明显上升(P<0.05)。围绝经期RLS/PLM患者肝郁积分与β-EP呈负相关(P<0.05),与RLS积分呈正相关(P<0.05);β-EP与RLS积分呈负相关(P<0.05)。结论血清β-EP水平可以为诊断围绝经期RLS/PLM肝郁的严重程度提供客观依据,临床上可以通过疏肝解郁缓解RLS/PLM的发作。

Objective:To observe the correlation between the liver depression score,β-endorphine(β-EP)and RLS score in perimenopausal women with restless legs syndrome/periodic leg movement(RLS/PLM),and thus provides objective evidence for clinical diagnosis and treatment.Methods:Enrolling 37 perimenopausal female of RLS/PLM with liver-depression type and 30 with non-liver-depression type.The difference ofβ-EP and RLS scores were compared between the two groups,and the correlation betweenβ-EP,liver depression scores and RLS scores were analyzed.Results:Compared with non-liver-depression group,β-EP in liver-depression group was obviously reduced,while the RLS scores were obviously increased(P<0.05).Liver depression score was negatively correlated withβ-EP(P<0.05),and positively correlated with RLS score(P<0.05).β-EP was negatively correlated with RLS score(P<0.05).Conclusion:The level of serumβ-EP can provide objective basis for diagnosing the severity of liver depression in perimenopausal women with RLS/PLM.It may relieve the attack of RLS/PLM by soothing liver to relieve Qi stagnation.