HPV、TCT+阴道镜检查用于早期宫颈病变筛查中的临床研究

Clinical study on application of HPV,TCT and colposcopy in early cervical lesion screening

目的评价高危型人类乳头状瘤病毒(HPV)、液基细胞学检查(TCT)+阴道镜检查用于早期宫颈病变筛查中的临床意义。方法选取我院2018年1~12月收治的198例疑似宫颈病变患者进行研究,采用随机数字表法将研究对象分为对照组与观察组,每组99例,对照组:予以HPV联合TCT检测,观察组:则采用HPV+TCT+阴道镜下宫颈活检,对比两组早期宫颈病变检出阳性率、不同疾病诊断价值。结果观察组的总检出率高于对照组,差异有统计学意义(χ2=11.992,P<0.05);观察组的SCC、HSIL的阳性预测值高于对照组,差异有统计学意义(P<0.05),观察组的SCC、HSIL、LSIL阴性预测值低于对照组,差异有统计学意义(P<0.05)。结论HPV+TCT+阴道镜下宫颈活检可提高早期宫颈病变总检出率,指导后期临床治疗,具有重要临床意义。

Objective To evaluate the clinical significance of application of high-risk human papilloma virus(HPV),liquid-based thinlayer cytology test(TCT)and colposcopy in early cervical lesion screening.Methods 198 with suspected cervical lesions who were admitted and treated in our hospital from January 2018 to December 2018 were selected as research objects.According to the random number table method,they were divided into the control group and the observation group,with 99 cases in each group.The control group was given HPV combined with TCT while the observation group was given HPV,TCT combined with colposcopic cervical biopsy.The positive rate of early cervical lesions and the diagnostic value of different diseases were compared between the two groups.Results The total detection rate in the observation group was higher than that in the control group,and the difference was statistically significant(χ2=11.992,P<0.05).The positive predictive values of SCC and HSIL in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The negative predictive values of SCC,HSIL and LSIL in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion HPV,TCT combined with colposcopic cervical biopsy can improve the overall detection rate of early cervical lesions and guide the later clinical treatment,which has important clinical significance.