布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入治疗支气管哮喘急性发作临床效果观察

Observation on clinical curative effects of budesonide and salbutamol combined with ipratropium bromide aerosol inhalation in treatment of acute attack of bronchial asthma

目的分析支气管哮喘急性发作患者应用布地奈德、沙丁胺醇联合异丙托溴铵治疗的效果。方法随机选取2017年6月~2018年6月在我院接受治疗的支气管哮喘急性发作患者70例并分为比对组(n=35)和探讨组(n=35),为所有患者提供抗感染、吸氧等常规治疗,在此治疗基础上比对组患者采用布地奈德、沙丁胺醇气雾剂治疗,探讨组患者应用布地奈德、沙丁胺醇联合异丙托溴铵治疗。结果探讨组患者胸闷消失时间短于比对组,两组差异有统计学意义(t=8.6632,P=0.0017),气喘消失时间较比对组患者短,两组差异有统计学意义(t=7.2736,P=0.0184),咳嗽消失时间短于比对组,两组差异有统计学意义(t=12.0283,P=0.0025),哮鸣音消失时间短于比对组,两组差异有统计学意义(t=10.3847,P=0.0152)。治疗后探讨组患者PEF占预计值高于对比组,差异有统计学意义(t=9.0276,P=0.0294),FEV1/FVC高于比对组,差异有统计学意义(t=16.0872,P=0.0161),FEV1高于比对组,差异有统计学意义(t=21.2083,P=0.0087)。比对组患者用药后不良反应总发生率为22.86%,探讨组不良反应总发生率为8.57%,两组差异有统计学意义(χ2=11.3074,P=0.0213)。结论支气管哮喘急性发作患者应用布地奈德、沙丁胺醇联合异丙托溴铵治疗可使其肺功能得到更加明显的改善,同时能够缩短其临床症状和体征消失的时间。

Objective To analyze the curative effects of budesonide and salbutamol combined with ipratropium bromide in the treatment of patients with acute attack of bronchial asthma.Methods 70 patients with acute attack of bronchial asthma who were treated in our hospital from June 2017 to June 2018 were randomly selected.They were divided into the control group(n=35)and the study group(n=35).All patients were given anti-infective,oxygen inhalation and other conventional treatment.On basis of it,patients in the control group were treated with budesonide and salbutamolaerosol.Patients in the study group were treated with budesonide and salbutamol combined with ipratropium bromide.Results The disappearance time of chest tightness in the study group was shorter than that in the control group,and the difference between the two groups was statistically significant(t=8.6632,P=0.0017).The disappearance time of asthma was shorter than that of the control group,and the difference between the two groups was statistically significant(t=7.2736,P=0.0184).The disappearance time of cough was shorter than that of the control group,and the difference between the two groups was statistically significant(t=12.0283,P=0.0025).The disappearance time of wheezing rale was shorter than that of the control group,and the difference between the two groups was statistically significant(t=10.3847,P=0.0152).After treatment,the PEF of the study group was higher than the control group,and the difference was statistically significant(t=9.0276,P=0.0294).FEV1/FVC was higher than that of the control group,and the difference was statistically significant(t=16.0872,P=0.0161).FEV1 was higher than that of the control group,and the difference was statistically significant(t=21.2083,P=0.0087).The total incidence of adverse reactions after treatment in the study group was 22.86%,and that in the study group was 8.57%.There were statistically significant differences between the two groups(χ2=11.3074,P=0.0213).Conclusion Budesonide and salbutamol combined with ipratropium bromide in the treatment of patients with acute attack of bronchial asthma can significantly improve the pulmonary function and shorten the disappearance time of clinical symptoms and signs in patients.