化疗后续用三苯氧胺对乳腺癌患者激素水平的影响

Effect of Chemotherapy Followed by Tamoxifen on Hormone Levels in Patients with Breast Cancer

目的探讨乳腺癌患者化疗后续用三苯氧胺对激素水平的影响。方法选取2015年1月~2018年12月我院收治的乳腺癌患者82例,采用随机数字表法分为继用三苯氧胺组(n=40)及停用三苯氧胺组(n=42),比较两组不同时间点(T0、T1、T2、T3、T4)E2、LH、FSH水平变化情况。结果两组E2水平均较治疗前升高,差异具有统计学意义(P<0.05);FSH、LH水平较治疗前升高,但差异无统计学差异(P>0.05)。继用三苯氧胺组不同时间点E2、FSH、LH水平比较,差异无统计学意义(P>0.05);停用三苯氧胺组T3、T4时间点E2水平较T1、T2时间点低,差异有统计学意义(P<0.05),不同时间点FSH、LH水平比较,差异无统计学差异(P>0.05)。结论化疗后续用三苯氧胺可影响乳腺癌患者E2水平,对于FSH及LH水平无明显影响,服用三苯氧胺期间对卵巢功能的判断应停药后多次测量。

Objective To investigate the effect of tamoxifen on hormone levels in patients with breast cancer after chemotherapy.Methods A total of 82 patients with breast cancer admitted to our hospital from January 2015 to December 2018 were enrolled.The randomized digital table method was divided into the tamoxifen group(n=40)and the tamoxifen group(n=42).The changes of E2,LH and FSH levels at different time points(T0,T1,T2,T3,T4)were compared between the two groups.Results The E2 levels in the two groups were higher than those before treatment,the difference was statistically significant(P<0.05).The levels of FSH and LH were higher than those before treatment,but the difference was not statistically significant(P>0.05).There were no significant differences in the levels of E2,FSH and LH between the tamoxifen groups at different time points(P>0.05).The levels of E2 at T3 and T4 in the tamoxifen group were lower than those at T1 and T2,the difference was statistically significant(P<0.05),there was no significant difference in FSH and LH levels at different time points(P>0.05).Conclusion The subsequent use of tamoxifen in chemotherapy can affect the E2 level of breast cancer patients.There is no significant effect on the levels of FSH and LH.The judgment of ovarian function during tamoxifen should be measured after repeated withdrawal.