新活素治疗低心排血量综合征的效果观察

Effect of Neonatal on Low Cardiac Output Syndrome

目的观察新活素(重组人脑利钠肽)治疗低心排血量(CO)综合征患者的临床疗效。方法收集2018年1月~2019年1月在我院心血管内科、CCU和河南省人民医院CCU住院的低心排血量综合征患者189例,采用随机数字表法分为常规治疗组和新活素治疗组。常规治疗组患者接受常规治疗,新活素治疗组患者在常规治疗组基础上加用新活素治疗,比较两组治疗前后收缩压、舒张压、心率、血肌酐水平、心脏指数、NT-pro-BNP及尿量。结果治疗后,两组患者心率、收缩压、舒张压、血肌酐、心脏指数等指标均较治疗前改善,差异有统计学意义(P<0.05);新活素治疗组患者心脏指数、NT-proBNP、尿量分别为(2.81±0.46)L/(min·m^2)、(452.53±62.13)pg/ml、(1206.56±64.52)ml/24h,均优于常规治疗组的(2.42±0.69)L/(min·m^2)、(525.23±66.25)pg/ml、(836.52±59.32)ml/24h,差异有统计学意义(P<0.05);两组收缩压、舒张压、血肌酐比较,差异无统计学意义(P>0.05)。结论在常规治疗低心排血量综合征基础上,给予新活素治疗,可以提高低心排血量综合征的疗效,改善患者生活质量,减少住院时间。

Objective To observe the clinical efficacy of neonatal(recombinant human brain natriuretic peptide)in the treatment of patients with low cardiac output(CO)syndrome.Methods A total of 189 patients with low cardiac output syndrome who were admitted to the Department of Cardiology,CCU and CCU of Henan Provincial People's Hospital from January 2018 to January 2019 were enrolled.The patients were randomly divided into the conventional treatment group and the new one.The active treatment group.Patients in the conventional treatment group received routine treatment.Patients in the neonatal treatment group were treated with neomycin in the conventional treatment group.The systolic blood pressure,diastolic blood pressure,heart rate,serum creatinine level,cardiac index,NT-pro-BNP and urine output.Results After treatment,the heart rate,systolic blood pressure,diastolic blood pressure,serum creatinine and cardiac index of the two groups were improved compared with those before treatment,the difference was statistically significant(P<0.05).The cardiac index,NT-pro-BNP and urine volume of the neonatal treatment group were(2.81±0.46)L/(min·m^2),(452.53±62.13)pg/ml,(1206.56±64.52)ml/24h,respectively,which were better than(2.42±0.69)L/(min·m^2),(525.23±66.25)pg/ml,(836.52±59.32)ml/24h in the conventional treatment group,the difference was statistically significant(P<0.05).There was no significant difference in systolic blood pressure,diastolic blood pressure and serum creatinine between the two groups(P>0.05).Conclusion On the basis of conventional treatment of low cardiac output syndrome,neonatal therapy can improve the efficacy of low cardiac output syndrome,improve patients'quality of life and reduce hospitalization time.