前列地尔辅助常规治疗冠心病不稳定型心绞痛的效果及对患者凝血功能的影响

Effect of Alprostadil on Routine Treatment of Unstable Angina Pectoris in Coronary Heart Disease and its Effect on Coagulation Function in Patients

目的观察前列地尔辅助常规治疗冠心病不稳定型心绞痛(UAP)患者的临床效果及其对患者血管内皮损伤和凝血功能的影响。方法选择我院2018年1月~4月收治的62例UAP患者,按照随机数字法分为研究组各对照组,各31例。对照组予以常规治疗,研究组在对照组的基础上联合前列地尔治疗。比较两组患者血浆ET、Hcy、纤维蛋白原(FIB)、D-二聚体、血清基质金属蛋白酶(MMP-2)、肿瘤坏死因子(TNF-ɑ)、白细胞介素(IL-6、IL-8)及高敏C反应蛋白(hs-CRP)水平。结果治疗后,研究组血浆ET、Hcy以及血清MMP-9水平分别为(80.41±8.49)pg/ml、(13.91±1.58)μmol/L、(183.61±18.58)ng/ml,均低于对照组的(96.68±9.74)pg/ml、(16.26±1.74)μmol/L、(224.13±21.94)ng/ml,差异有统计学意义(P<0.05);研究组FIB和D-二聚体水平分别为(2.91±0.23)g/L、(0.36±0.08)mg/L,均低于对照组的(3.67±0.32)g/L、(0.63±0.09)mg/L,差异有统计学意义(P<0.05);研究组血清hs-CRP、TNF-ɑ、IL-6、IL-8水平分别为(2.58±0.31)mg/L、(2.46±0.17)μg/L、(76.21±7.49)ng/L、(16.21±1.69)ng/L,均低于对照组的(3.72±0.25)mg/L、(3.15±0.18)μg/L、(87.31±8.49)ng/L、(18.51±1.23)ng/L,差异有统计学意义(P<0.05)。结论UAP患者采用前列地尔辅助常规治疗可有效降低血管内皮损伤,缓解炎症反应,降低血液黏度,改善患者预后。

Objective To investigate the effect of alprostadil in the treatment of patients with unstable angina pectoris(UAP)and its effects on vascular endothelial injury and coagulation function.Methods 62 patients with UAP admitted to our hospital from January to April 2018 were enrolled.According to the random number method,the study group and the control group were divided into 31 cases.The control group received routine treatment,and the study group was treated with alprostadil on the basis of the control group.Plasma ET,Hcy,fibrinogen(FIB),D-dimer,serum matrix metalloproteinase(MMP-2),tumor necrosis factor(TNF-ɑ),Interleukin(IL-6,IL-8)and high-sensitivity C-reactive protein(hs-CRP)levels.Results After treatment,plasma ET,Hcy and serum MMP-9 levels in the study group were(80.41±8.49)pg/ml,(13.91±1.58)μmol/L,and(183.61±18.58)ng/ml,respectively,which were lower than the control group(96.68±9.74)pg/ml,(16.26±1.74)μmol/L,(224.13±21.94)ng/ml,the difference was statistically significant(P<0.05);the study group FIB and D-dimer levels were respectively(2.91±0.23)g/L,(0.36±0.08)mg/L,which were lower than(3.67±0.32)g/L and(0.63±0.09)mg/L in the control group,the difference was statistically significant(P<0.05);serum hs-CRP,TNF-ɑ,IL-6,IL-8 levels in the study group were(2.58±0.31)mg/L,(2.46±0.17)μg/L,(76.21±7.49)ng/L,(16.21±1.69)ng/L,were lower than the control group(3.72±0.25)mg/L,(3.15±0.18)μg/L,(87.31±8.49)ng/L,(18.51±1.23)ng/L,the difference was statistically significant(P<0.05).Conclusion The use of alprostadil in the UAP patients can effectively reduce vascular endothelial injury,relieve inflammation,reduce blood viscosity and improve patient prognosis.