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血清分泌型卷曲相关蛋白5与Ⅱ型糖尿病关系的研究进展

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摘要 糖尿病的“炎症学说”认为,Ⅱ型糖尿病(T2DM)是一种慢性低浓度的炎性反应,炎症在T2DM的发生发展中具有重要的媒介作用。分泌型卷曲相关蛋白5(SFRP-5)是新发现的一种具有抗炎作用的脂肪因子,与T2DM及其并发症关系密切,文章对SFRP-5的抗炎作用机制进行了概述,就SFRP-5与T2DM肥胖、脂质代谢以及炎症反应关系的研究现状进行了综述,旨为T2DM等代谢性疾病中SFRP-5作用机制的研究提供参考和借鉴。
出处 《黔南民族医专学报》 2019年第3期224-227,共4页 Journal of Qiannan Medical College for Nationalities
基金 2016年贵阳市卫生计生委高层次创新型青年卫生人才培训计划项目(2016014)
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  • 1Patricia M García-García,María A Getino-Melian,Virginia Domínguez-Pimentel,Juan F Navarro-Gonzalez.WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Inflammation in diabetic kidney disease[J].World Journal of Diabetes,2014,5(4):431-443. 被引量:26
  • 2洪梅,魏文宁,杨锐,杨焰,宋善俊.IL-10对IL-6诱导外周血单个核细胞组织因子表达的调节作用[J].中国实验血液学杂志,2005,13(3):479-482. 被引量:11
  • 3孙芳毅,王书彩,郭丽敏.白介素—10与急性冠脉综合征[J].实用心脑肺血管病杂志,2007,15(4):314-316. 被引量:2
  • 4Ouchi N, Higuchi A, Ohashi K, et al. Sfrp5 is an anti - inflammatory adipokine that modulates metabolic dysfunction in obesity [ J ]. Sci- ence, 2010, 329 (5990): 454-457.
  • 5Mori H, Prestwich TC, Reid MA, et al. Secreted frizzled - related pro-tein- 5 suppresses adipocyte mitochondrial metabolism through WNT in- hibition [J]. J Clin Invest, 2012, 122 (7): 2405-2416.
  • 6Schulte DM, Moiler N, Neumann K, et al. Pro -inflammatory wnt5a and anti - inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects [ J]. PLoS One, 2012, 7 (2) : e32437.
  • 7Carstensen M, Herder C, Kempf K, et al. Sfrp5 correlates with insulin resistance and oxidative stress [ J ]. Eur J Clin Invest, 2013, 43 (4) : 350 -357.
  • 8Hu Z, Deng H, Qu H. Plasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistance [ J]. Diabetes Res Clin Pract, 2013, 99 (3): 391-395.
  • 9Lv C, Jiang Y, Wang H, et al. Sfrp5 expression and secretion in adi- pocyte are up - regulated during the differentiation and are negatively cor- related with insulin resistance [J]. Cell Biol Int, 2012, 36 (9): 851 -855.
  • 10Andrews hi, Soto N, Arredondo M. Effect of mefformin on the expres- sion of tumor necrosis factor - x, Toll like receptors 2/4 and C reactive protein in obese type -2 diabetic patients [J]. Rev Med Chil, 2012, 140 (11): 1377-1382.

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