摘要
非编码RNA在细胞生物学功能中发挥着重要作用。近年来,研究人员在生物发育和多种疾病中发现了一些由非编码RNA(ncRNA)编码产生的多肽或蛋白质。在本文中,我们简要总结了几种由ncRNA翻译的微肽分子及其功能。此外,我们还总结了调控ncRNA的可能机制,并且提出了一个生物“开关”,即细胞在一定的刺激或应激状态下,能够触发ncRNA分子由非编码状态到编码状态的转换。ncRNA的潜在编码特性及其微肽产物为蛋白质组学研究提供了一个新的视角,有希望为多种疾病提供新的治疗靶点。
Noncoding RNAs(ncRNAs)have played a critical role in cellular biological functions.Recently,some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases.Here,we briefly review several novel peptides translated by annotated ncRNAs and related key functions.In addition,we summarize the potential mechanism of bifiinctional ncRNAs and propose a specific"switch"triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress.
