阿戈美拉汀与氟哌噻醇美利曲辛治疗围绝经期综合征的对照研究

A comparative study of agomelatine and flupentixol and melitracen in the treatment of perimenopausal syndrome

目的:比较阿戈美拉汀与氟哌噻醇美利曲辛治疗围绝经期综合征的疗效差异。方法:选取门诊围绝经期综合征患者50例,随机分为阿戈美拉汀组(25例)和氟哌噻醇美利曲辛组(25例)。入组第1周给予阿戈美拉汀25 mg/d或氟哌噻醇美利曲辛1片/d,随后剂量由医师根据病情需要调整,阿戈美拉汀剂量不超过50 mg/d,氟哌噻醇美利曲辛不超过2片/d。用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)总分和减分率评定疗效。结果:阿戈美拉汀和氟哌噻醇美利曲辛均能有效改善围绝经期妇女的抑郁症状(P<0.01);第4周阿戈美拉汀组改善焦虑症状方面优于氟哌噻醇美利曲辛组(P<0.01),差异有显著性;但在第8周末,阿戈美拉汀组总有效率92%(23/25),氟哌噻醇美利曲辛组总有效率为84%(21/25),两组疗效差异无统计学意义。两组治疗期间的不良反应差异无统计学意义(P>0.05)。结论:经8周治疗,阿戈美拉汀和氟哌噻醇美利曲辛对围绝经期综合征抑郁和焦虑均具有较好的疗效,且两者疗效相当,但阿戈美拉汀起效快,尤其在改善焦虑症状方面。

Objective:To compare the curative effect of agomelatine and flupentixol and melitracen in the treatment of perimenopausal syndrome.Method:Fifty outpatients with perimenopausal syndrome were randomly divided into two groups:agomelatine group(25 cases)and flupentixol and melitracen group(25 cases).In the first week of the study,25 mg/QN of agomelatine or flupentixol and melitracen 1 tablet/QD was taken,and the dosage was adjusted by the physician according to the need of the outpatients.The dose of agomelatine was not more than 50 mg/QN and 2 tablets/QD respectively.The efficacy was evaluated by Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA).Results:Both agomelatine and flupentixol and melitracen could effectively improve the depressive symptoms of perimenopausal women(P<0.01),which has statistical significance.At the end of the 4th week,the effect of agomelatine group on improving anxiety symptoms was better than that of flupentixol and melitracen group(P<0.01).However,after 8 weeks of treatment,the total effective rate of agomelatine group was 92%(23/25),the total effective rate was 84%(21/25)in flupentixol and melitracen group,which had no significant difference;and also there was no difference in adverse reactions between the two groups(P>0.05).Conclusion:After 8 weeks of treatment,bothagomelatine and flupentixol and melitracen have a good effect on depression and anxiety in outpatients with perimenopausal syndrome,and both have the same effect.But agomelatine worked more quickly,especially in improving anxiety symptoms.